PLGA-coated Biphasic Calcium Phosphate in Sinus Lift

Status Completed

Clinical Trial Summary

The study aims to investigate the radiological and histomorphometric results of the use of PLGA-coated biphasic calcium phosphate granules in sinus floor elevation, to analyze the underlying molecular processes by immunohistochemical staining, and to evaluate the handling of the biomaterial and the in situ hardening properties.

A randomized clinical study is designed to include patients in need of two-stage sinus floor elevation. Patients are assigned to receive either PLGA-coated biphasic calcium phosphate particles (group I) or the equivalent but non-coated particles (group II). CBCT scans are performed before and 6 months after the procedure to assess the bone height gain. At the time of implant placement, bone core biopsies are obtained at the site of implant placement. Histological sections are subjected to histomorphometric and immunohistochemical evaluation of differentiation markers.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Sinus Floor Augmentation

Clinical Trial Details

NCT number	NCT03474627
Study type	Interventional
Source	Universidad de Granada
Contact
Status	Completed
Phase	N/A
Start date	February 2012
Completion date	March 2017

View Details

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