Sinus Arrhythmia Clinical Trial
Background: Sinus node dysfunction is a major cause of bradycardia necessitating pacemaker
implantation. Evidences of genetic study supported that some genes involved in the pacemaker
current or renin-angiotensin system were related to sinus node dysfunction. However, the
influence of gene polymorphisms on sinus node dysfunction was not well studied.
Methods: A group of 100 patients with documented sinus node dysfunction and 100 age- and
sex- matched healthy control patients will be enrolled into this study. Gene polymorphism
study includes the angiotensin-I converting enzyme gene, angiotensin II type 1 receptor
gene, HCN1-4, SCN5A, KCNE and other possible gene polymorphisms which are related to sinus
node function based on previous reports. Genetic polymorphisms are identified with
polymerase chain reaction-based restriction analysis. Comparison of multiple haplotype
analysis and single-locus analysis will be analyzed between the cases and controls.
Estimated Results: Some genetic polymorphisms of these genes which are related to sinus node
function or rennin-angiotensin system will show association with sinus node dysfunction. In
multilocus haplotype analysis, some genetic haplotype profiles may demonstrate significant
difference between cases and controls. In single locus analysis, some genetic polymorphisms
may be associated with sinus node dysfunction.
Estimated Conclusion and Clinical Implication: This study will demonstrate the genetic
polymorphisms in RAS genes or some other genes associated with sinus node dysfunction. These
results will support the roles of these genetic polymorphisms in determining the risk of
sinus node dysfunction among the Chinese population in Taiwan.
n/a
Observational Model: Case Control, Primary Purpose: Screening, Time Perspective: Longitudinal
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