Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical Reconstruction

Single Ventricle Defect Clinical Trial

— CBF  

Official title:

A Magnetic Resonance Imaging Study to Determine Cerebral Blood Flow Changes in Single Ventricle Patients During Staged Reconstruction as Compared to Normal Children

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02135081
• Other study ID #: 08-006166
• Secondary ID: 1R01HL090615-01A
• Status: Completed
• First received: April 17, 2014
• Last updated: March 15, 2018
• Start date: December 2008
• Est. completion date: November 2016

Study information

• Verified date: March 2018
• Source: Children's Hospital of Philadelphia
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study seeks to determine cerebral blood flow changes in single ventricle patients during staged surgical reconstruction as compared with normal children. Two general groups of single ventricle patients will be recruited for this study, corresponding to the two approaches used. An aged-match group of healthy subjects will be included as a control.

Description:

This is a prospective, non-randomized, single center study designed to measure and determine the changes in cerebral blood flow in a cohort of single ventricle patients followed across all three stages of surgical (Fontan) reconstruction. In addition, cerebral blood flow response to hypercarbia will be determined after the first 2 operations as a measure of cerebral blood flow reserve and the "intactness" of the cerebral autoregulatory system. MRI data from this cohort will be compared with that collected in age-matched healthy children and in a cross sectional group of patients who will not necessarily be followed through all stages of surgery, but may undergo one or two of the MRI evaluations depending on their stage of surgery. Neurological exams and EEGs will be performed. Medical history, cardiac catheterization data, where available, will also be collected. Factors such as cardiopulmonary bypass time and socioeconomic class will be controlled for.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 260
• Est. completion date: November 2016
• Est. primary completion date: June 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 4 Months to 10 Years

Eligibility

Inclusion Criteria - Single Ventricle Subjects:

• Males or females up to age 10 years.

• Any complex congenital heart lesion that has single ventricle physiology. These single ventricle lesions will be of either right or left ventricular morphology.

• Ability to undergo an MRI scan of at least 60-90 minutes under general anesthesia or deep sedation. Patients will undergo determination of their physical ability to undergo the MRI prior to being enrolled in the study by parameters such as blood pressure, heart rate, cardiac rhythm, and respiratory rate. MRI involves laying still in the supine position for at least 60-90 minutes.

• Parents signing informed consent.

Inclusion Criteria - Normal Control Group:

• Males or females up to age 10 years.

• Normal cerebral anatomy who are normocephalic and who are asymptomatic (e.g. if the scan is performed for headache) at the time of the scan.

• Ability to undergo an MRI scan of at least 60-90 minutes under general anesthesia or deep sedation. Normal patients will undergo determination of their physical ability to undergo the MRI prior to being enrolled in the study by parameters such as blood pressure, heart rate, cardiac rhythm, and respiratory rate. MRI involves laying still in the supine position for at least 60-90 minutes.

• Parents signing informed consent.

Exclusion Criteria - Single Ventricle Patients :

• Any condition judged by the patient's physician that would cause this trial to be detrimental to the patient.

• Stenosis of the branch pulmonary arteries or coarctation of the aorta.

• Any significant arrhythmias such as supraventricular tachycardia, trigeminy, etc. Occasional premature atrial or ventricular contractions or an occasional missed beat is permitted.

• Systemic hypertension.

• Primary lung disease (eg bronchopulmonary dysplasia).

• Any known significant neurological disease outside of the usual state of single ventricle patients.

• Any chromosomal anomalies or other major anomalies which would confound neurological outcome.

• A patient with a pacemaker or cardioverter/defibrillator in place.

• A ferromagnetic foreign body (with the exception of sternal wires and vascular clips in the thorax).

• Parents/guardians or subjects who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures.

Exclusion Criteria - Normal Control Group:

• Any condition judged by the patient's physician that would cause this trial to be detrimental to the patient.

• Any known significant neurological disease

• Any contraindication to performing an MRI.

• Parents/guardians or subjects who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures.

Related Conditions & MeSH terms

• Single Ventricle Defect

Locations

Country	Name	City	State
United States	Children's Hospital of Philadelphia	Philadelphia	Pennsylvania

Sponsors (3)

Lead Sponsor	Collaborator
Children's Hospital of Philadelphia	National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Age related CBF changes between 4-6 months to 3-10 years.	Determine age related CBF changes in a group of normal children from ages 4-6 months to 3-10 years undergoing clinical brain MRIs for other reasons and found not to have pathology.	Up to 2 hours
Primary	Cerebral blood flow changes throughout staged surgical reconstruction in single ventricle patients.	Cerebral blood flow & systemic blood flow will be measured via MRI in addition to cerebral anatomy and volume at all 3 stages.	Up to 2 years
Secondary	CBF in single ventricle patients compared to CBF of age-matched normal children.		Up to 2 years
Secondary	CBF reserve and "intactness" of the cerebral regulatory mechanisms after Stage I and hemi Fontan/bidirectional Glenn stage of surgeries.	Determine CBF reserve and "intactness" of the cerebral regulatory mechanisms in patients after Stage I and hemi Fontan/bidirectional Glenn stage of surgeries by obtaining CBF under normal conditions and under conditions of hypercarbia prior to surgery.	Up to 2 years
Secondary	CBF reserve after Stage 1 compared with CBF reserve in hemi Fontan/bidirectional Glenn stage of surgeries.		Up to 2 years