Single Nucleotide Polymorphism Clinical Trial
— FolGeneOfficial title:
Pilot Study to Investigate Relationship Between Common Folate Gene Polymorphisms, Folate Status and Cellular Folate Speciation
Verified date | February 2013 |
Source | Institute of Food Research |
Contact | n/a |
Is FDA regulated | No |
Health authority | United Kingdom: National Health Service |
Study type | Observational |
This pilot study is designed to investigate differences in folate-related genes (single nucleotide polymorphisms) and their relationship to the species of folate present on red blood cells.
Status | Completed |
Enrollment | 100 |
Est. completion date | December 2010 |
Est. primary completion date | July 2010 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Aged 18-65 - Males and females - Body Mass Index greater than 19.5 and less than 40 - Smokers and non-smokers Exclusion Criteria: - Pregnancy or been pregnant in last 12 months - Diabetes - Parallel participation in another research project if total amount of blood from combined studies is greater than 470ml - Participation in another research project where blood samples were taken within the past 4 months, unless total blood volume does not exceed 470ml - Any person related to or living with a member of the study team - Has donated or intends to donate blood within 16 weeks (prior to or after) the study |
N/A
Country | Name | City | State |
---|---|---|---|
United Kingdom | Institute of Food Research | Norwich | Norfolk |
Lead Sponsor | Collaborator |
---|---|
Institute of Food Research |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Relationship between MTHFR TT, CT and CC genotype and red cell folate species | July 2010 | No | |
Secondary | Relationship between other folate metabolism related genes and red cell folate species | July 2010 | No | |
Secondary | Relationship between folate, B12, riboflavin and ferritin status and red cell folate species | December 2010 | No |
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