Single Nucleotide Polymorphism Clinical Trial
Official title:
Association of Genetic Polymorphisms With Lipid Lowering Effects of Statin Therapy
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, also known as statins, played an important role in lipid-lowering therapy and reduction of cardiovascular risks. However, it has been observed that the response to statin therapy varies from patient to patient, and gene polymorphism could have contributed to the variation.
Hyperlipidemic patients are retrospectively screened from 2006/1/1 to 2006/12/31. The
patient is included if he or she had been receiving atorvastatin or rosuvastatin for at
least 3 months and did not receive other lipid-lowering medications 4 weeks before starting
atorvastatin or rosuvastatin. Genomic DNA was collected from the blood sample of each
patient using genomic DNA purification kit. The single nucleotide polymorphisms (SNPs) were
determined afterward.
The correlation between response of statin therapy, defined as changes in lipid profiles
including triglyceride, total cholesterol, high density lipoprotein cholesterol and low
density lipoprotein cholesterol, and SNPs examined.
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Observational Model: Case-Only, Time Perspective: Prospective
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