Simple Diverticular Disease Clinical Trial
Official title:
Prospective Randomized Clinical Trial for the Management of Uncomplicated Diverticulitis in Right Colon; Non-antibiotics Versus Antibiotics
The aim of the present study was to evaluate whether antibiotics is mandatory for the
treatment of acute uncomplicated right-sided diverticulitis.
The hypothesis is that patients having acute uncomplicated diverticulitis at right-sided
colon will be recovered without antibiotics.
All patients in the study were randomly allocated to one of the following two treatment
groups; no-antibiotics group or antibiotics group.
Patients of no-antibiotics group were admitted to the ward and administered intravenous
fluid and bowel rest at least up to 5 days until clinical symptom and sign were stabilized.
And then the patient discharge until oral intake was tolerated.
In antibiotics group, the treatment was initiated with an intravenous combination of a third
generation cephalosporin or quinolone and metronidazole until oral intake was tolerated.
Oral antibiotics such as cefpodoxime together with metronidazole were initiated subsequently
on the ward. The total duration of antibiotic treatment was an expected average 10days.
Patients in both group were re-visited outpatient clinic after an expected average 7 days
for check-up of serology test (including complete blood count and C-reactive protein), and
after an expected average 6 weeks for CT. If the patients did not re-visit outpatient
clinic, we checked the call.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT01831323 -
Evaluation of the Metabolome in Diverticular Disease
|
N/A |