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Clinical Trial Summary

An observational cohort study that will assess the efficacy of Whole Lung Lavage in workers with silicosis or silica-induced bronchitis.


Clinical Trial Description

BACKGROUND: Silicosis is a fatal lung disease caused by inhaling silica particles. Australia is currently facing an epidemic with hundreds of young workers having contracted silicosis from machining engineered stone. AIMS: To determine the effectiveness and safety of Whole Lung Lavage (WLL) in workers with silicosis due to significant engineered stone exposure. DESIGN: Participants (30) with silicosis or silica-induced bronchitis who are scheduled to undergo WLL as part of their normal care will be enrolled. They will undergo the following interventions pre and 3 months post WLL, some of which would have been carried out as part of routine standard care: 1. Complex pulmonary function tests (PFTs) - standard care 2. HRCT scan (if not within 6 months of WLL) - standard care 3. Blood tests 4. Cardiopulmonary exercise testing 5. Forced oscillatory technique 6. XV Lung Ventilation Analysis 7. Questionnaires (K-BILD and LCQ) ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05402176
Study type Observational
Source The University of Queensland
Contact Daniel Chambers
Phone (07) 3646 7498
Email daniel.chambers@health.qld.gov.au
Status Not yet recruiting
Phase
Start date June 2022
Completion date December 2024

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