Assessing Cerebrovascular Reactivity Based on Cerebral Oximetry: a Pilot Study

Signs and Symptoms Clinical Trial

— DOSI  

Official title:

Assessing Cerebrovascular Reactivity Based on Cerebral Oximetry

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01483495
• Other study ID #: 20107521
• Status: Completed
• Start date: December 2011
• Est. completion date: December 2011

Study information

• Verified date: October 2022
• Source: University of California, Irvine
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The brain is such a metabolically active organ that it consumes about 20% of oxygen burned every minute by an average adult even though it only contributes about 2% of the body weight. As a result, the brain produces a disproportionately high amount of CO2 every minute in comparison with the rest of the body.

Description:

The researcher can use Diffuse Optical Spectroscopy Imaging, cerebral non-invasive oximetry instrument, to determine cerebrovascular reactivity during surgery procedure. Specifically, the cerebral tissue O2 saturation can measure by Diffuse Optical Spectroscopy Imaging can use for cerebral blood flow in the evaluation of cerebrovascular reactivity.

Adequate brain perfusion is critical not only to supply oxygen and nutrients but also to wash out metabolic end products including CO2. Blood flow depends on perfusion pressure and vascular bed resistance. It is well known that multiple physiological and pathological factors affect cerebral vasculature, and the resistance to blood flow. The cerebrovascular responsiveness to those factors determines how well the brain can maintain and adjust its perfusion.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 78
• Est. completion date: December 2011
• Est. primary completion date: December 2011
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

1. Male or Female 20 years of age and older

2. Female non-pregnant

3. Subject scheduled for elective surgery under general anesthesia with intubation.

4. Subject who is able to give informed consent.

Exclusion Criteria:

1. Less than 20 years old of age

2. Pregnant woman

3. Subjects currently diagnosed with severe hypertension, myocardial ischemic disease, symptomatic valvular disease(s), symptomatic arrhythmia, uncompensated congestive heart failure, intracranial aneurysm.

Related Conditions & MeSH terms

• Brain Ischemia
• Hypoxia
• Hypoxia-Ischemia, Brain
• Ischemia
• Signs and Symptoms

Intervention

Device:
• Diffuse optical spectroscopy
Diffuse Optical Spectroscopy Imaging Cerebrovascular Reactivity

Locations

Country	Name	City	State
United States	UCI Beckman Laser Institute	Irvine	California

Sponsors (2)

Lead Sponsor	Collaborator
University of California, Irvine	Beckman Laser Institute University of California Irvine

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brain blood flow	Optical Imaging assess of Brain blood flow during surgical procedure	6 hours