Clinical Trials Logo
  1. Home
  2. Signs and Symptoms
  3. NCT01277276

Study of Chemotherapy Side Effects in Cancer Patients: Non-invasive Optical Measurements of the Brain

Signs and Symptoms Clinical Trial

Official title:
Study of Chemotherapy Side Effects in Cancer Patients: Non-invasive Optical Measurements of the Brain

Clinical Trial Summary

Currently there is no methodology that can assign a risk of development of chemo brain and thus, studies to understand how and why only some patients develop chemo brain along with studies of potential treatments face major hurdles. This study will define hemodynamic/optical parameters in normal individuals and cancer patients undergoing chemotherapy potentially identifying optical parameters that are associated with the development of chemo brain, leading to new insights into the origin of the chemo brain condition, and importantly potentially identifying parameters that may predict who will develop "chemo brain" in order to directing investigations of therapies.

Clinical Trial Description

The researcher can use Non-invasive optical imaging, diffuse optical spectroscopic imaging, measure various tissues and can determine chemo brain symptoms. Near infrared diffuse optical imaging is a real-time, non-invasive technique that measures hemodynamic variations based on changes in hemoglobin oxygenation. Tissue in general and the cerebral cortex surface in particular, are transparent to near infrared light. Direct optical measurement of cerebral hemodynamic parameters is superior to systemic approaches that infer brain levels of hemoglobin. Optical imaging in conjunction with physiologic maneuvers measures vascular tone and reactivity and may permit early detection of changes in physiology that precede the onset of chemo brain symptoms. Since chemo brain specifically impacts working memory and executive function the optical imaging can measure the frontal cortical areas behind the forehead. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01277276
Study type Observational
Source University of California, Irvine
Contact
Status Withdrawn
Phase
Start date November 2008
Completion date February 2013
View Details
See also
  Status Clinical Trial Phase
Completed NCT03273114 - Cognitive Functional Therapy (CFT) Compared With Core Training Exercise and Manual Therapy (CORE-MT) in Patients With Chronic Low Back Pain N/A
Completed NCT00378989 - The Effectiveness of Health Advice and Occupational Health Intervention on Work Ability N/A
Withdrawn NCT02689817 - Monitoring Physiologic Data in the Development of Pressure Ulcers N/A
Completed NCT02826408 - Effect of Proton Pump Inhibitors on Palpitations N/A
Recruiting NCT02913365 - Etiologies, Investigations and Outcomes of Patients Presenting With Hemoptysis N/A
Recruiting NCT01708668 - The Effects of Intermittent Epidural Bolus on Fever During Labor Analgesia N/A
Completed NCT00784108 - Optimizing Photodynamic Therapy of Cutaneous Neoplastic Diseases Via Structured Illumination and Real-time Dosimetry. Phase 1
Completed NCT00230932 - Help Veterans Experience Less Pain Study (HELP-Vets) N/A
Recruiting NCT00173706 - Evaluation of the Effects of L-Carnitine Injection in Patients Undergoing Hemodialysis Phase 4
Terminated NCT01192594 - Milestones of Adjustment Post-Psychosis Phase 3
Completed NCT04606199 - Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity N/A
Withdrawn NCT01814293 - Comparison of Supportive Therapies for Symptom Relief From Pediatric Upper Respiratory Infections (URIs) N/A
Completed NCT01483703 - Noninvasive Optical Measurement of Critical Care Neonates
Completed NCT04260035 - The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) in Episodic Migraine Patients N/A
Completed NCT01340027 - A Study to Evaluate the Efficacy, Safety and Tolerability of Mirabegron and Solifenacin Succinate Alone and in Combination for the Treatment of Overactive Bladder Phase 2
Completed NCT03471923 - Non-Motor Features of Cervical Dystonia (CD)
Completed NCT03544268 - Academic-Industrial Partnership for Translation of Acoustic Angiography Phase 4
Completed NCT01954199 - The Effectiveness of Neurodynamic Techniques in Patients With Nerve-Related Leg Pain N/A
Recruiting NCT01551238 - Energy Expenditure, Sleep and Macronutrients N/A
Completed NCT01715376 - Effects of Integrated Treatment by Traditional Chinese and Western Medicine in Reducing Cardiovascular Events