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Bone Marrow Transplant From Related Donor for Patients With High Risk Hemoglobinopathies

Sickle Cell Anemia Clinical Trial

Official title:
Allogeneic Bone Marrow Transplant From HLA Identical Related Donors for Patients With High Risk Hemoglobinopathies: Hemoglobin SS, Hemoglobin SC, Hemoglobin SB0/+ Thalassemia, or Homozygous B0/+ Thalassemia or Severe Variants of B0/+ Thalassemia

Clinical Trial Summary

The major goal of this study is to determine the risks and benefits of bone marrow transplants in patients with severe thalassemia or sickle cell disease. Participation in this project will be for two years.

Clinical Trial Description

To do the bone marrow transplant, we must first kill the cells in the bone marrow that make the abnormal red blood cells that are found in patients with severe thalassemia or sickle cell disease.

We will do this by using three drugs: busulfan, cyclophosphamide, and CAMPATH-1H. CAMPATH-IH is an investigational drug. CAMPATH-1H is used to prevent participants from rejecting or refusing to let the donor blood cells grow in the body. After the drug treatment, participants will be given bone marrow from a brother or sister who has healthy bone marrow that matches. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00040469
Study type Interventional
Source Baylor College of Medicine
Contact
Status Terminated
Phase Phase 2
Start date August 2000
Completion date November 21, 2003
View Details
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