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Vasopressin Versus Norepinephrine for the Management of Shock After Cardiac Surgery — VaNCS  

Shock Clinical Trial

Clinical Trial Summary

Vasoplegic syndrome after cardiac surgery is a common complication after cardiac surgery, with negative impact on patient outcomes and hospital costs. Pathogenesis of vasodilatory phenomenon after cardiac surgery remains a matter of controversy. Loss of vascular tone can be partly explained by the depletion of neurohypophyseal arginine vasopressin stores. The investigators hypothesized that the use of arginine vasopressin would be more effective on treatment of shock after cardiac surgery than norepinephrine, decreasing the composite end point of mortality and severe morbidity.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01505231
Study type Interventional
Source University of Sao Paulo
Contact Ludhmila Hajjar, MD, PhD
Phone 55-11-93194401
Email ludhmila@usp.br
Status Recruiting
Phase Phase 3
Start date January 2012
Completion date May 2013
View Details
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