Shock, Septic Clinical Trial
Official title:
Strategy of Early Improvement of Tissue Oxygenation Decrease the Mortality of Severe Sepsis
Verified date | March 2011 |
Source | Chinese Septic Shock Network |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The impact of lactate guided therapy on septic shock has not been extensively investigated,
however the goal directed therapy has been used for years. The investigators aim was to test
the hypothesis that lactate directed hemodynamic therapy is associated with improving the
outcome of patients with septic shock by comparing different goal directed strategies which
have been commonly recommended clinically.
In this multicenter, randomized trial, the investigators assigned patients with septic shock
to three groups: Patients were treated with hemodynamic therapy directed either by
conventional parameters treatment (control group), or central venous oxygen saturation
(ScvO2), or blood lactate respectively in each group. The primary outcome was the rate of
death at 28 days after randomization and in-hospital mortality; secondary end points include
hemodynamic states, time to goal-achievement.
Status | Completed |
Enrollment | 420 |
Est. completion date | October 2009 |
Est. primary completion date | October 2009 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - severe sepsis and septic shock patients Exclusion Criteria: - <18 years old; - pregnant woman; - AMI; - cerebral hemorrhage; - contraindication for S-G catheter - Brainstem death |
Country | Name | City | State |
---|---|---|---|
China | Critical Care Department, Peking Union Medical Hospital | Peking |
Lead Sponsor | Collaborator |
---|---|
Chinese Septic Shock Network |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | mortality | Because some patients stayed in hospital for a quite long time,so when we made statistics,we defined that if the patient still alive after involved 90 days, this patient was in-hospital lived. | in-hospital |
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