Metabolic Implications of Day and Night-shift Working on NHS Healthcare Staff — MIDNIGHT  

Shift-work Disorder Clinical Trial

Official title: Metabolic Implications of Day and Night-shift Working on NHS Healthcare Staff

Status Recruiting

Clinical Trial Summary

The investigators will conduct an open label, experimental medicine study exploring the acute metabolic impact of night-shift compared to day-shift work in NHS healthcare workers. Employees who are scheduled to work both day and night shifts will be recruited and identical metabolic investigations will be performed in the same participant following at least 3 consecutive day and night-shifts respectively. These investigations will take place at the Clinical Research Unit (CRU) in Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) at Churchill Hospital. The order of post-day and post-night shift investigations will be randomly determined and there will be a 2-week minimum interval between both sets of investigations. Participants will complete a self-reported food diary before and during each set of shifts (both day and night) and will have wrist-watch actigraphy performed throughout the entire study period in order to measure sleep and activity parameters. All study visits and investigations will commence at the CRU at 8am and will include a 2-step hyperinsulinaemic euglycaemic clamp with stable isotope infusions.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Shift-work Disorder

• NCT number: NCT05962112
• Study type: Observational
• Source: University of Oxford
• Contact: Thomas Marjot
• Phone: 07816566933
• Email: thomas.marjot@ndm.ox.ac.uk
• Status: Recruiting
• Start date: April 1, 2022
• Completion date: April 1, 2024