Sexual Function Disturbances Clinical Trial
Official title:
Urinary and Sexual Functions After Subtotal Versus Total Abdominal Hysterectomy
All hysterectomies were performed intrafascially using the clamp-cut-ligate method as
described by (Jones, 2003);
Careful examination under anesthesia.
Catheterization by N. 18 Foley's catheter and its balloon Filled with 10-ml saline.A
transverse lower abdominal incision (Pfannenstiel incision) ranging from 8-12 cm through
which the abdomen is opened in layers.
During subtotal hysterectomy procedure, the corpus is amputated just below the level of the
isthmus and then the endocervical canal is electrocoagulated using monopolar electrocautery.
The cervical stump is closed using vicryl 0 sutures.
During total hysterectomy procedure, the urinary bladder is dissected off the lower uterine
segment of the uterus and cervix by blunt or sharp dissection. Blunt dissection is done
using a finger pushed gently against the cervix rather than against the bladder. Sharp
dissection using Metzenbaum scissors is performed in patients with previous cesarean
sections, with upward traction on the bladder peritoneum and the uterine fundus stretched
tightly out of the pelvis, the tips of the Metzenbaum scissors rest lightly on the fascia
overlying the cervix with small bites to develop a tissue plane, dissecting the bladder from
the anterior cervix.
Revision of all pedicles to ensure hemostasis.
Intraoperative antibiotics (1 gm of a 3rd generation cephalosporin + 0.5 gm metronidazole).
The abdomen is closed in layers; the wound is covered with a sterile dressing. All specimens
were sent for pathological examination in the pathology Unit.
All hysterectomies were performed intrafascially using the clamp-cut-ligate method as
described by (Jones, 2003);
Careful examination under anesthesia.
Catheterization by N. 18 Foley's catheter and its balloon Filled with 10-ml saline.
A transverse lower abdominal incision (Pfannenstiel incision) ranging from 8-12 cm through
which the abdomen is opened in layers.
During subtotal hysterectomy procedure, the corpus is amputated just below the level of the
isthmus and then the endocervical canal is electrocoagulated using monopolar electrocautery.
. The cervical stump is closed using vicryl 0 sutures.
During total hysterectomy procedure, the urinary bladder is dissected off the lower uterine
segment of the uterus and cervix by blunt or sharp dissection. Blunt dissection is done
using a finger pushed gently against the cervix rather than against the bladder. Sharp
dissection using Metzenbaum scissors is performed in patients with previous cesarean
sections, with upward traction on the bladder peritoneum and the uterine fundus stretched
tightly out of the pelvis, the tips of the Metzenbaum scissors rest lightly on the fascia
overlying the cervix with small bites to develop a tissue plane, dissecting the bladder from
the anterior cervix.
Revision of all pedicles to ensure hemostasis.
Intraoperative antibiotics (1 gm of a 3rd generation cephalosporin + 0.5 gm metronidazole).
The abdomen is closed in layers; the wound is covered with a sterile dressing. All specimens
were sent for pathological examination in the pathology Unit.
Post-operative care;
After ensuring complete recovery, the patient was transferred to the ward with close follow
up of the vital signs every 15 minutes till stable, then every 2 hours for 24 hours, then
every 8 hours till discharge.
Postoperative antibiotics (1 gm of a 3rd generation cephalosporin + 0.5 gm metronidazole)
were given eight hourly for 24 hours then stopped (Hager, 2003).
Postoperative analgesics (Non-steroidal anti-inflammatory drugs) were given eight hourly for
24 hours then if needed
Intravenous fluids were given for the 1st 8 hours postoperative and then fluid diet was
allowed with early ambulation and deep breathing (Horowitz and Basil, 2003).
The urinary catheter was removed 24 hours postoperatively.
Upon discharge, the patients were advised to resume work and sexual intercourse only after 4
weeks . An appointment was given to the patients to be seen 6 months after the operation.
Pre- and post-operative evaluation
The patients were interviewed and examined preoperatively and 6 months postoperative.
I. Urinary function was evaluated before surgery and 6 months afterward using;
A. Subjective questionnaire to detect urinary Symptoms including:
1. Diurnal frequency of micturition (voids >6 times a day).
2. Nocturia (waking at night more than one time to void).
3. Urge urinary incontinence. (urine leakage related to a feeling of urgency).
4. Stress urinary incontinence. (urine leakage related to physical activity, coughing or
sneezing).
5. Dysuria (stinging/burning sensation).
6. Hesitancy (difficulty in initiating micturition).
7. Reduction of the stream (compared to previous performance).
8. Sensation of incomplete bladder emptying.
9. Haematuria.
B. Physical examination:
Stress test: With the bladder near full, the patient was asked to cough vigorously while
watching for leakage of urine .
Evaluate levator ani muscle function by asking the patient to tighten her "vaginal muscles".
C. Objective urodynamic studies: urodynamic evaluation was done for all participants in the
study. All urodynamic studies were performed using ANDROMEDA M00101-2 ELLIPSE.
The following tests were done:
1. Filling cystometry; the following parameters were evaluated and compared ;
First desire to void (The point at which the woman first experiences an awareness of
the need to empty her bladder).
Maximum cystometric capacity (The point at which the woman can delay micturition no
longer).
Maximum detrusor pressure reached during filling phase.
2. Uroflowmetry:
Where the maximum flow rate and the residual volume were identified.
Method
1. The patient presented with a symptomatically full bladder. She voided spontaneously in
a uroflow chair. Maximum flow rate and postvoid residual urine volume were obtained via
a transurethral catheter.
2. The microtransducer catheters were connected to the appropriate cables and to the
tubing from the water pump.
3. With the patient in the supine position on a urodynamic chair, the abdominal catheter
was placed into the vagina . A dual microtransducer 6-French catheter with a filling
port was then placed into the bladder . The patient was moved to a sitting position.
4. After the catheters were appropriately placed, the subtraction was checked by asking
the patient to cough. Cough-induced pressure spikes should be seen on the Pves and Pabd
channels, but not on the true detrusor pressure channel.
5. The urinary bladder was filled with normal saline at room temperature with a filling
rate 50-100 ml/min. First desire to void and strong desire to void were recorded.
Throughout the filling portion of the examination, the patient was asked to perform
provocative activities, such as coughing and straining. The external urethral meatus
was constantly observed for any involuntary urine loss.
Sexual function: The patients were interviewed before surgery and 6 months afterward and
sexual function was evaluated using a subjective questionnaire measuring the following
sexual variables :
1. Libido (desire): It is described as perceiving sexual desire once a week or more, which
is a subjective feeling state.
2. Frequency of intercourse (once a week or more).
3. Dyspareunia (painful coitus).
4. Frequency of orgasm: the most intense pleasure followed by sudden release of the
tension that has built up during excitement. It is described as (always or often).
5. Sense of vaginal dryness.
6. Satisfaction with sexual life (satisfied-not satisfied).
The patients were allowed to resume sexual intercourse 4 weeks after the operation.
Data collection included:
1. Postoperative recording of operation time, intra-operative blood transfusion (if
needed), length of hospital stay, and pathology of the removed uterus.
2. Postoperative complications including pyrexia, vault haematoma, wound haematoma, wound
infection, vaginal bleeding, need for blood transfusion, postoperative pain, cervical
stump prolapse, and vaginal vault prolapse.
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