Severe Sepsis Clinical Trial
Official title:
Descriptive Study of the Evolution in Proportion of Regulatory B Lymphocytes in Patients Hospitalized in Intensive Care for Severe Sepsis
Severe sepsis and septic shock are the most severe forms of sepsis (which associates a
systemic inflammatory response with infection). These are serious pathologies with a
lethality estimated at almost 40% at 28 days (after the onset of sepsis).
After a first pro-inflammatory phase, a second compensatory phase called Compensatory
Anti-Inflammatory Response Syndrome (CARS) takes place quickly. Patients then show signs of
immunosuppression and profound alterations in immune functions. It is during this phase that
the vast majority of deaths occur, far from the onset of the shock, which is related to the
inability of the immune system to eliminate the initial infectious agent and / or a greater
susceptibility Important to develop secondary infections (nosocomial infection, latent virus
reactivation ...).
The CARS phase has been the subject of studies focusing on measuring the plasma
concentration of anti-inflammatory cytokines (such as Interleukin (IL) -10), the percentage
of regulatory T lymphocytes (Treg), Or the percentage of monocytic expression of HLA-DR in
septic patients.
The investigator proposes to carry out the first study on a newly described regulatory
lymphocytic subpopulation: regulatory B lymphocytes (Breg) from a quantitative and
functional point of view in severe septic states.
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