Severe Sepsis Clinical Trial
Official title:
Comparative Study of the Protein C Pathway in Septic and Non Septic Patients
This is a comparative study performed in 3 groups of patients/subjects: 30 severe sepsis
patients, 30 non-septic patients with organ failure, 30 healthy subjects.
The only intervention is a venous blood sampling at the onset of the disease.
The purpose of the study is to compare the PC pathway and expression and inflammatory genes
between the 3 groups. The main hypothesis is that systemic inflammatory response and
exacerbated coagulation activation are non specific of an infection as a triggering event.
Status | Terminated |
Enrollment | 90 |
Est. completion date | October 2003 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - severe sepsis patients or: - non-septic acute organ failure patients or: - healthy subjects matched for age and sex with severe sepsis patients Exclusion Criteria: - criteria for organ failure lasting for more than 24 hours |
Observational Model: Case Control, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Assistance Publique - Hôpitaux de Paris | Institut National de la Santé Et de la Recherche Médicale, France |
Borgel D, Clauser S, Bornstain C, Bièche I, Bissery A, Remones V, Fagon JY, Aiach M, Diehl JL. Elevated growth-arrest-specific protein 6 plasma levels in patients with severe sepsis. Crit Care Med. 2006 Jan;34(1):219-22. — View Citation
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