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Comparative Study of the Protein C Pathway in Septic and Non Septic Patients With Organ Failure

Severe Sepsis Clinical Trial

Official title:
Comparative Study of the Protein C Pathway in Septic and Non Septic Patients

Clinical Trial Summary

This is a comparative study performed in 3 groups of patients/subjects: 30 severe sepsis patients, 30 non-septic patients with organ failure, 30 healthy subjects.

The only intervention is a venous blood sampling at the onset of the disease.

The purpose of the study is to compare the PC pathway and expression and inflammatory genes between the 3 groups. The main hypothesis is that systemic inflammatory response and exacerbated coagulation activation are non specific of an infection as a triggering event.

Clinical Trial Description

analysis of the PC pathway

- PC activity

- PS activity

- soluble thrombomodulin

- soluble EPCR

- activated protein C

- quantitative flow cytometry on monocytes (thrombomodulin and EPCR)

- whole blood mRNA (Tissue factor, thrombomodulin and EPCR)

- inflammatory gene expression analysis by MLPA ;

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00361725
Study type Observational
Source Assistance Publique - Hôpitaux de Paris
Contact
Status Terminated
Phase N/A
Start date March 2003
Completion date October 2003
View Details
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