Clinical Trials Logo

Clinical Trial Summary

Pre-eclampsia (PE) is one of the most frequent pregnancy complications and is one of the main causes of maternal and fetal morbidity and mortality in its severe form.control of blood pressure is of crucial importance to avoid maternal and fetal complications.Therapeutic modalities that can target the underlying pathophysiological changes and reverse the endothelial dysfunction could help to ameliorate the systemic manifestations in patients with severe PE. Either Intravenous labetalol and nitroglycerine as well as sublingual nifedipine have been frequantly used for the management of acute severe hypertension in PE


Clinical Trial Description

Pre-eclampsia (PE) is one of the most frequent pregnancy complications and is one of the main causes of maternal and fetal morbidity and mortality in its severe form. Pre-eclampsia characterized by - Rising blood pressure (BP ≥ 140/90 that occurs after 20 weeks of gestation in a woman with previously normal BP. - . Proteinuria (≥300mg/24hr . This correlates with 30mg/dl or ≥1+ on urine dipstick) - Edema control of blood pressure is of crucial importance to avoid maternal and fetal complications. The pathophysiology of pre-eclampsia is most likely inadequate placentation, leading to endothelial dysfunction and reduced nitric oxide bioavailability. Therapeutic modalities that can target the underlying pathophysiological changes and reverse the endothelial dysfunction could help to ameliorate the systemic manifestations in patients with severe PE. Either Intravenous labetalol and nitroglycerine as well as sublingual nifedipine have been frequantly used for the management of acute severe hypertension in PE . Nitroglycerine, a nitric oxide donor with low oral bioavailability and a very short half-life, has a potent venodilator effect in low doses and affects arterial tone at high doses Labetalol is useful as it contains both selective, competitive, alpha1-adrenergic antagonism and non-selective, competitive, beta-adrenergic (B1 and B2) blocking activity in a single agent Nifedipine is a dihydropyridine calcium channel blocker. Its main uses are as an antianginal and antihypertensive ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06265415
Study type Interventional
Source Sohag University
Contact diaa A abdelaal, resident
Phone 01064451169
Email deaaaly@med.sohag.edu.eg
Status Not yet recruiting
Phase N/A
Start date March 30, 2024
Completion date March 30, 2025

See also
  Status Clinical Trial Phase
Terminated NCT04725812 - Complement Regulation to Undo Systemic Harm in Preeclampsia Phase 2
Active, not recruiting NCT03744988 - Serum Androgen Levels as a Marker for the Severity of Preeclampsia
Completed NCT02189148 - First-trimester Prediction of Preeclampsia
Completed NCT04058405 - Risk Prediction Models for Adverse Maternal and Neonatal Outcomes in Preeclampsia
Completed NCT03164304 - Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia Phase 4
Completed NCT02379832 - Pre-Eclampsia And Growth Restriction: a Longitudinal Study
Not yet recruiting NCT01538121 - Antiphospholipid Antibodies and Early Severe Preeclampsia. N/A
Recruiting NCT01906567 - İs There a Relationship Between Severity of Preeclampsia and Maternal Heavy Metal Levels? N/A
Recruiting NCT01382732 - Carbetocin vs. Oxytocin for Prevention of Postpartum Bleeding in Patients With Severe Preeclampsia Phase 3
Completed NCT01408979 - Effectiveness Study of Short Course of Magnesium Sulfate for Severe Preeclamsia Phase 4
Completed NCT01538147 - Restless Leg Syndrome and Severe Preeclampsia N/A
Terminated NCT03008616 - Study of the Efficacy and Safety of AMAG-423 (Digoxin Immune Fab) in Antepartum Subjects With Severe Preeclampsia Phase 2/Phase 3