Severe Pre-Eclampsia, Antepartum Clinical Trial
Official title:
Oral Nifedipine Versus IV Labetalol in Treatment of Severe Pre Eclampsia in Pregnancy
OBJECTIVE: To determine the efficacy of nifedipine and labetalol in terms of control of BP in
pre eclamptic pregnant patients
Design: Randomised control trial
SETTING: Department Obstetrics & gynaecology, Services Hospital, Services Institute of
Medical Sciences. Lahore
POPULATION: Pregnant patients with BP 160/110 or symptoms of severe preeclampsia
METHODS: Patients are randomised to receive nifedipine (10 mg tablet, orally, up to five
doses) and intravenous placebo saline injection or intravenous labetalol injection (in an
escalating dose regimen of 20, 40, 80, 80 and 80 mg) and a placebo tablet every 15 minutes
until the target blood pressure of ≤140/90mmHg is achieved. Crossover treatment is given if
the initial treatment regimen is unsuccessful
Gestational hypertension is associated with increased risk of maternal morbidity and
mortality. Parenteral therapy needs more resources, more monitoring and supervision. Oral
therapy is cheap, easily available, easy to administer especially in resource constrained
settings
OBJECTIVE: To determine the efficacy of nifedipine and labetalol in terms of control of BP in
pre eclamptic pregnant patients
Design: Randomised control trial SETTING: Department Obstetrics & gynaecology, Services
Hospital, Services Institute of Medical Sciences.Lahore POPULATION: Pregnant patients with BP
160/110 mm Hg or symptoms of severe preeclampsia
METHODS: Patients are randomised to receive nifedipine (10 mg tablet, orally, up to five
doses) and intravenous placebo saline injection or intravenous labetalol injection (in an
escalating dose regimen of 20, 40, 80, 80 and 80 mg) and a placebo tablet every 15 minutes
until the target blood pressure of ≤140/90mmHg is achieved. Crossover treatment is given if
the initial treatment regimen is unsuccessful
;