Clinical Trials Logo
  1. Home
  2. Severe Malaria
  3. NCT02451904

Severe and Cerebral Malaria Investigated Through Host Metabolomics

Severe Malaria Clinical Trial

Official title:
Microvascular and Metabolic Dysregulation in the Pathogenesis of Severe and Cerebral Malaria Investigated Through Host Metabolomics

Clinical Trial Summary

- The aim is to describe disease mechanisms of severe and cerebral malaria and identify new targets for adjunctive therapies.

- Despite treatment between 10-30% of patients with severe malaria die.

- Metabolic acidosis and cerebral malaria are major complications associated with mortality across all age groups. Still, their underlying pathogenesis remains incompletely understood.

- Using a metabolomics approach, this study aims to characterise the spectrum of acids accumulating during acidosis, and investigate patterns of metabolic dysregulation associated with coma and seizures.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02451904
Study type Observational
Source University of Oxford
Contact
Status Completed
Phase
Start date June 2015
Completion date September 2017
View Details
See also
  Status Clinical Trial Phase
Completed NCT01955382 - Evaluation of Oral Activated Charcoal on Antimalarial Drug's Ability to Kill Parasites in Malian Children With Malaria Phase 2
Not yet recruiting NCT01122134 - Pharmacokinetics and Pharmacodynamics of Intravenous Artesunate for Severe Malaria Treatment N/A
Recruiting NCT04675931 - To Evaluate Efficacy, Safety, Tolerability and PK of Intravenous Cipargamin in Participants With Severe Plasmodium Falciparum Malaria Phase 2
Recruiting NCT05685875 - Association of Diabetes and Metabolic Syndrome With Severe Malaria in Cameroon
Completed NCT04037332 - Monitoring of Molecular Markers of Artemisinin Resistance Through Repeated Cross-sectional Assessments in DR Congo, Nigeria and Uganda
Completed NCT00341003 - Severe Malaria and Anti-malarial Drug Resistance in Cambodia N/A
Completed NCT01255215 - Inhaled Nitric Oxide for the Adjunctive Therapy of Severe Malaria: a Randomized Controlled Trial Phase 1/Phase 2
Completed NCT05140278 - Study to Compare Feasibility of 1-step Injectable Artesunate vs. Conventional 2-step Injectable Artesunate Phase 2
Recruiting NCT05711485 - Platelet-Directed Whole Blood Transfusion Strategy for Malaria N/A
Completed NCT04473768 - Clinical Decision Support in Non-typhoidal Salmonella Bloodstream Infections in Children
Completed NCT04176029 - Lung Ultrasound in Children With Severe Malaria
Recruiting NCT06064591 - Host Immune and Metabolic Determinants of Sexual Conversion in Plasmodium Parasites IMMETASEX
Recruiting NCT04251351 - Effect of Paracetamol on Kidney Function in Severe Malaria Phase 3
Completed NCT00342043 - Examination of Protective Factors Against Severe Malaria N/A
Completed NCT04516317 - Very Severe Malaria Treated by Intravenous Artesunate
Completed NCT01828333 - Malaria Treatment With Injectable ArteSunate N/A