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Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia — SHASTA-3  

Severe Hypertriglyceridemia Clinical Trial

Official title:
Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults With Severe Hypertriglyceridemia

Clinical Trial Summary

This Phase 3 study will evaluate the safety and efficacy of plozasiran injection (ARO-APOC3) in adult participants with severe hypertriglyceridemia (SHTG). After providing informed consent eligible participants will be randomized to receive 4 doses (once every 3 months) of plozasiran or placebo, and be evaluated for efficacy and safety. After month 12, eligible participants will be offered an opportunity to continue in an optional open-label extension under a separate protocol.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06347003
Study type Interventional
Source Arrowhead Pharmaceuticals
Contact Medical Monitor
Phone 626-304-3400
Email plozasiran@arrowheadpharma.com
Status Recruiting
Phase Phase 3
Start date June 2024
Completion date October 2026
View Details
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