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Safety and Early Efficacy Study of TBX-1400 in Patients With Severe Combined Immunodeficiency

Severe Combined Immunodeficiency Clinical Trial

Official title:
Safety and Early Efficacy Study of TBX-1400 in Patients With Severe Combined Immunodeficiency

Clinical Trial Summary

This is a study of stem cell transplantation with TBX-1400 in pediatric subjects with severe combined immunodeficiency (SCID).

The donor cells are exposed to a protein that has been shown in the laboratory to improve the ability of the donor cells to make blood and immune cells after transplant. Exposure of the donor cells to this protein does not modify the genes in the cells in any way.

This study has two goals. The first goal is to find out if transplant with TBX-1400 is safe. The second goal is to find out what effects TBX-1400 stem cells have on time to engraftment in pediatric subjects with SCID. The study hypothesis is that TBX-1400 cells will shorten the time to immune reconstitution after transplant.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02860559
Study type Interventional
Source Taiga Biotechnologies, Inc.
Contact Yosef Refaeli, Dr.
Phone +1-720-859-3547
Email refaeli@taigabiotech.com
Status Not yet recruiting
Phase Phase 1
Start date August 2021
Completion date March 2024
View Details
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