Septic Shock Clinical Trial
Official title:
REAnimation Low Immune Status Markers
The fact that sepsis disrupts immune system homeostasis by inducing an initial cytokine
storm, that participates to occurrence of organ failures and early death, followed by a
compensatory anti-inflammatory response leading to immunosuppression, is now well
established. This immunomodulating response results in a higher risk of secondary infections
and is associated to 2/3 of deaths related to septic shocks. Follow up of patients' immune
status with time is crucial to guide therapy management. Objective of REALISM project is to
demonstrate existence of this immunosuppression phase, by providing strong epidemiologic data
for septic shock patients, but also by extension to other situations of inflammatory
aggressions like severe severe trauma or burns, or major surgery. This project will provide
tools to predict occurrence of secondary infections and guide patient management by comparing
innovating immunomonitoring tools to reference tests non already adapted to a routine patient
management.
Targeted populations are adult patients hospitalized for septic shock, severe trauma
(including severe burn) or major surgery and healthy volunteers, whom blood samples will
serve to validate reference intervals of the two reference tests.
n/a
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