Severe Brain Injury Clinical Trial
Official title:
Study of PtiO2 Variation by Body Temperature and Capnia in Severe Head Trauma Patients With Intracranial Refractory Hypertension Treated With Targeted Temperature Control
Serious head trauma is a common and pathology and responsible of high morbidity and
mortality. The major challenge, from the very first hours, is to limit cerebral ischemia by
controlling secondary brain injury factors.
These parameters must be integrated early in order to guide the better cerebral
resuscitation. Brain monitoring is multimodal:transcranial Doppler, intracranial pressure
sensor, cerebral tissue pressure in O2.
In the case of refractory intracranial hypertension to well-conducted medical treatment,
targeted temperature control showed its efficacy on the control of intracranial pressure.
There are few data in the literature on PbtO2 modifications during therapeutic hypothermia.
PbtO2 monitoring is now commonly used according to literature data, showing the benefit of
the latter but the interpretation of its values during the phase of targeted temperature
control is not known. Due to the lack of data on the variation of values of PbtO2 during the
hypothermia phase, values falsely comfortable or falsely weak could lead respectively to a
lack of support of an episode of tissue hypoxia or the introduction of unjustified aggressive
therapeutics.
This is a prospective, non-interventional, mono-centric study at surgical intensive care unit
at Brest medical university hospital.
This study will be conducted in a reference center for the management of patients with
traumatic brain injury, who is used to collect prospective data.
The clinical research structure of Brest Medical University allows data analysis and the
investigators have the clinical knowledge for their interpretation.
After verification of the inclusion and non-inclusion criteria and information of the family
(parent or relative) or the holder of parental authority, patients will be included in order
of arrival in the service.
The population studied is the trauma brain injured patients with an initial Glasgow coma
scale of less than 8 at pre-hospital care or neurological impairment with Glasgow Coma
Scaleless than 8 in the first 24 hours after admission to intensive care.
The installation of a intra-cranial pressure/ PbtO2 probe (INTEGRA Licox PtO2 monitor) is
performed by the neurosurgeon according to the protocol service.
Approximately 30 patients were monitored with a PbtO2 sensor in 2018 in the Surgical
intensive care unit at Brest Medical University Hospital.
After verification of inclusion and non-inclusion criteria, oral and written information will
be given to parent or relative of the patient. A no-objection form will be sent to the
patient as soon as possible to confirm his participation.
Follow-up of the patient is carried out until discharge of intensiv care unit. The duration
of participation in the study is the duration of treatment by targeted temperature control,
very variable depending on the clinical evolution of patients, from 1 day to more than one
week. The management of the patients included in this study is not modified in relation to
the treatment usually recommended in the intensiv care unit.(based on French recommendation).
In order to describe the variations of PbtO2 values, the PbtO2 values are collected at time
T0 before induction of targeted temperature control, at time T1: the first hour of the
targeted temperature control phase (<35 ° C) at time T2: during the phase of temperature
stability (<35 ° C) defined as two successive hours of hypothermia, at time T3 defines as 6
hours at a stable temperature in hypothermia, then once a day up to the end of the targeted
temperature control phase.
Then the values of PtiO2 are collected during the daily hypercapnia test during targeted
temperature control phase.
Demographic data collected are age, sex, weight, height, and data on gravity at the entrance:
IGS2 score, first Glasgow Coma scale score, time to CT-scan and IMPACT score.
Data on time to PbtO2 probe and ICP probe insertion and time to equilibration of PbtO2 value.
Data were collected at all times, T0, T1, T2, T3 (as defined above) and daily: the body
temperature (collected by esophageal thermal probe), the cerebral perfusion pressure, the
value of PtiO2 / PIC, FiO2 / etCO2, an arterial blood sample, a blood count and a daily
ionogram,daily transcranial Doppler data, doses of amines, curares and sedation.
During the stay were collected: time to and nature of the surgical procedure and realization
of a craniectomy or not, position of the PtiO2 probe on a control scanner, an at the
discharge: prognosis score (GOS-E),lenght of stay in intensive care unit, death in intensive
care unit.
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