Severe Asthma Clinical Trial
Official title:
Clinico-biological Correlation of Severe Asthma in Children
Asthma is the most common chronic respiratory disorder in children. Despite significant
advances in understanding of asthma, available therapies fail to alter the natural history
and progression of the disease. Airway epithelial cells are continuously exposed to and
injured by environmental irritants, such as viruses and pollutants, and as such are ideally
situated to orchestrate airway function in response to these stimuli.
Severe or difficult-to-treat asthma in children is a complicated disorder characterized by
ongoing symptoms and persistent airway inflammation and oxidant stress despite
corticosteroid treatment. Although severe asthma is likely a heterogeneous disorder,
affected children similar clinical features, including gas trapping, bronchial
hyperresponsiveness, and aeroallergen sensitization. However, the molecular and cellular
pattern of inflammation in children with severe asthma are not uniform : some investigators
have found increased eosinophils and TH2 derived cytokines, others have noted
noneosinophilic patterns with neutrophil activation.
Given the heterogeneity of the inflammatory response in children with severe asthma,
additional methods to distinguish severe asthma are needed.
n/a
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label
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