View clinical trials related to Severe Aortic Stenosis.
Filter by:SUMMARY: The investigators are planning a clinical study to compare two methods of performing a procedure called TAVI, used in patients with severe aortic stenosis. In this procedure, the aortic valve is replaced in a less invasive way. Traditionally, access through the groin (femoral) is used, but now radial access (through the wrist) is being considered as an alternative. Reasons for the Study: - Currently, there is not enough solid evidence to support the choice between these two accesses. - The investigators want to understand if radial access could be safer and have fewer complications compared to femoral access. What the Investigators Will Measure: - Major complications, such as bleeding or vascular injuries. - Other important outcomes, such as functional recovery and quality of life. How the Investigators Will Do It: - The investigators will randomize patients to receive radial or femoral access. - The investigators will record which type of access is used and assess complications and outcomes. - The investigators will compare the results to understand if there are significant differences between the two groups. Ultimate Goal: - The investigators aim to improve the safety and efficacy of this procedure for patients. - The results of this study will help doctors make informed decisions on how to perform TAVI. Conclusion: - This study is crucial for enhancing care for patients with aortic stenosis and ensuring the procedure is performed in the safest and most effective manner. The results will benefit patients and guide doctors in choosing the best approach for each individual.
ATTR-cardiac amyloidosis (CA) is present in 4% to 16% of elderly patients with severe calcific aortic stenosis (AS). The reasons for this association are not fully known. It is hypothesized that an amyloidotic infiltration of the aortic valve acts as a trigger for the development of endothelial damage and subsequent calcification. Elderly patients undergoing TAVI will be evaluated for the presence of ATTR-CA in Jordan.
The purpose of this study is to demonstrate that transcatheter artificial aortic valve and transcatheter artificial heart values delivery system is associated with a reduction of all-cause mortality in severe aortic stenosis or insufficiency patients who are high risk or ineligible for aortic valve replacement.