Clinical Trials Logo
  1. Home
  2. Septicemia
  3. NCT03943719
  4. Details
NCT03943719 Clinical Trial

Clinical Impact of the FilmArray Blood Culture Identification Panel Performed on Positive Blood Cultures From Intensive Care Patients With Septicemia

Septicemia Clinical Trial

— SEPSIS2016  

Official title:
The Impact of a Rapid Molecular Identification Test on Positive Blood Cultures From Critically Ill With Bacteremia: a Pre-post Intervention Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03943719
Other study ID # SEPSIS2016
Secondary ID 2016/19SEP/401
Status Completed
Phase
First received
Last updated
Start date March 1, 2017
Est. completion date August 31, 2018

Study information
Verified date May 2019
Source Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Contact n/a
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

Molecular testing is a largely validated approach allowing rapid identification of positive blood cultures. However, due to its high cost and its limited information on susceptibility, it is considered as an add-on technique reserved for specific patient populations. In our study, we specifically evaluated molecular testing in a critical care setting and measured its impact on the therapeutic management of critically ill with positive blood cultures. Through the analysis of 110 positive blood culture episodes included in both pre- and post intervention period, we measured a drastic 14h-reduction of the time to administration of the optimal antimicrobial treatment with the use of the molecular approach.

Recruitment information / eligibility
Status Completed
Enrollment 139
Est. completion date August 31, 2018
Est. primary completion date December 31, 2017
Accepts healthy volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- adult intensive care unit patients with positive blood cultures

Exclusion Criteria:

- palliative care patients

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• FilmArray blood culture identification panel
FilmArray blood culture identification panel is performed 24 hours on 24hours and 7 days a week on positive blood cultures to accelerate pathogens detection

Locations
Country Name City State
Belgium Cliniques universitaires St-Luc Brussels

Sponsors (2)
Lead Sponsor Collaborator
Cliniques universitaires Saint-Luc- Université Catholique de Louvain BioMérieux

Country where clinical trial is conducted

Belgium, 

Outcome
Type Measure Description Time frame Safety issue
Primary Turn Around Time to optimal treatment of septicemia Time in minutes From positivity detection of positive blood culture to administration of optimal treatment (up to 48 hours)
See also
  Status Clinical Trial Phase
Enrolling by invitation NCT04764058 - Efficacy and Safety of Colistin Based Antibiotic Therapy Phase 1/Phase 2
Completed NCT03088865 - Evaluation of an Internal Hospital Practice: The Effect of Altered Test Tubes Sampling Order on Blood Culture Contamination Rates N/A
Completed NCT00046072 - A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis Phase 2
Completed NCT01520597 - National Study on Listeriosis and Listeria
Recruiting NCT03929159 - Correlating MicroRNA Changes With Sepsis Outcomes
Completed NCT00901940 - Understanding the Immune Response to Meningitis Vaccines Phase 3
Not yet recruiting NCT03583762 - Time to Appropriate Antibiotic Between Using Microarray Assay and Mass Spectrometry Technique N/A
Completed NCT02988414 - Diagnosis of Bacteremia/Septicemia and Culture Negative Endocarditis by the Karius Sequencing-Based Infectious Disease Diagnostic Assay
Completed NCT02102087 - Study to Evaluate the Effectiveness of the Initial Specimen Diversion Device N/A
Recruiting NCT05045963 - Impact of Aminoglycosides in Hypotensive Septic Oncology Patients
Terminated NCT02093494 - Study to Evaluate the Effectiveness of the Initial Specimen Diversion Device When Collected Through Peripheral Intravenous Catheters N/A
Active, not recruiting NCT02069028 - Effectiveness of Different Interventions for Implementing Surviving Sepsis Campaign (SSC) Guidelines on Compliance and Mortality: Systematic Review and Meta-analysis N/A
Recruiting NCT00258869 - Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests N/A
Completed NCT05358912 - Efficacy of Targeted Abdominal Perfusion Pressure in Septic Shock Phase 4
Recruiting NCT05893420 - A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning N/A
Recruiting NCT05040503 - Monitoring Mitophagy In Myeloid Cells Upon Intensive Care N/A
No longer available NCT04636554 - Personalized Phage Treatment in Covid-19 Patients With Bacterial Co-Infections Microbials for Pneumonia or Bacteremia/Septicemia
Completed NCT00146432 - Immunoadsorption of LPS, C5a and IL-6 in Severe Sepsis and Septic Shock (ISASS-1) Phase 2/Phase 3