Septicemia in Hemodialysis Clinical Trial
Official title:
PCR Technic Evaluation in the Microbial Diagnostic of Septicemia in Hemodialysis Patients With Catheter.
The aims of this study are to evaluate the PCR on whole blood approach to determine rapidly both the susceptibility and the identification of Staphylococcus responsible of septicemia in patients under hemodialysis with catheter. The results obtained with this novel experimental approach will be compared to those obtained on the same clinical samples by the routine diagnostic laboratory.
The outlook of current trends indicates that maximum effort is needed to tailor the initial
antimicrobial therapy in patients under hemodialysis with catheter. Specific emphasis is put
on early availability of antimicrobial susceptibility results by Diagnostic laboratories to
optimize the management of those difficult infections.
Direct whole blood PCR could allow a rapid determination of bacterial susceptibility to
antibiotics. The study is designed to assess the concordance of a direct whole blood PCR
targeting staphylococcus and its susceptibility to oracillin with the classical
microbiological approach of samples from hemodialysis patients with catheter suspected of
septicemia. This innovative approach should allow a faster diagnostic allowing the clinicians
to better tailor the initial empirical antimicrobial therapy which has been proven crucial
for a good clinical management of the patients.
Moreover, the use of an adequate antimicrobial therapy early in the management of the
patients, should not only lead to a better clinical outcome but also avoid unnecessary
prescriptions of drugs which are the main drivers of the emergence and spread of
antimicrobial resistance.
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