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The Diagnostic and Prognostic Value of Presepsin in Sepsis

Septic Shock Clinical Trial

Official title:
PRESEPSIN: Biomarker in the Early Diagnosis of Sepsis

Clinical Trial Summary

Intra-abdominal infections are a common cause of sepsis and frequently occur in intensive care unit (ICU) patient. Various markers such as procalcitonin, presepsin and endotoxin are used to identify patients at risk of sepsis or to guide proper treatment. No studies compared presepsin to procalcitonin and endotoxin in patients treated with by extracorporeal hemoperfusion with a polymyxin-B-adsorbing cartridge (PMX-HA).

Clinical Trial Description

Intra-abdominal infections are a common cause of sepsis and frequently occur in intensive care unit (ICU) patient. Various markers such as procalcitonin, presepsin and endotoxin are used to identify patients at risk of sepsis or to guide proper treatment. Particularly, endotoxin can be removed from the blood by extracorporeal hemoperfusion with a polymyxin-B-adsorbing cartridge (PMX-HA). No studies compared presepsin to procalcitonin and endotoxin in patients treated with PMX-HA. The investigators aim to evaluate the trend and prognostic value of presepsin versus procalcitonin and endotoxin in ICU patients with septic shock from complicated major abdominal surgery, treated with PMX-HA. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06180265
Study type Interventional
Source University of Foggia
Contact
Status Completed
Phase N/A
Start date February 1, 2020
Completion date July 19, 2023
View Details
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