Effects of Terlipressin on Renal Perfusion in Patients With Septic Shock

Status Completed

Clinical Trial Summary

This open-label, randomized controlled trial aimed to investigate the effect of a fixed dose of terlipressin added to usual care vs. usual care alone on renal perfusion in patients with septic shock.

Clinical Trial Description

Terlipressin is a synthetic vasopressin analog with great affinity to the V1 receptor (vasoconstrictive effect), and could selectively contract efferent arterioles, increase glomerular filtration pressure and renal perfusion. The investigators conducted this open-label, randomized controlled trial to observe the effects of a fixed dose of terlipressin added to usual care vs. usual care alone on renal perfusion in patients with septic shock. Renal perfusion was monitored by renal contrast-enhanced ultrasound. The primary outcome was peak intensity (renal perfusion parameter) at 24 hours after enrollment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04948372
Study type	Interventional
Source	Southeast University, China
Contact
Status	Completed
Phase	N/A
Start date	September 1, 2019
Completion date	June 28, 2020

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