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Effects of Dexmedetomidine vs Midazolam on Microcirculation in Septic Shock Patients

Septic Shock Clinical Trial

Official title:
Effects of Dexmedetomidine vs Midazolam on Microcirculation in Septic Shock Patients: a Muscle Microdialysis Study

Clinical Trial Summary

To investigate changes in the concentration of glucose, lactate, pyruvate and glycerol in the extracellular fluid of the skeletal muscle following Dexmedetomidine administration in patients with septic shock.

Clinical Trial Description

Prospective randomized double blinded study. Investigators planned to enroll 60 cases diagnosed with septic shock All patients will be sedated with Midazolam and remifentanyl in accordance with a local unit protocol.

After a period of six hours of hemodynamic stability, patients were randomized to receive either continuous infusion of Dexmedetomidine at 0.4 μg/kg per hour and remifentanyl (DEX group) or a continuous infusion of a Midazolam and remifentanyl (MDZ Group). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03434691
Study type Interventional
Source Military Hospital of Tunis
Contact Zied Hajjej
Phone 0021620358907
Email hajjej_zied@hotmail.com
Status Recruiting
Phase N/A
Start date February 8, 2018
Completion date December 31, 2018
View Details
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