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Candida Host Defense Response After Septic Shock in the Critically Ill — IMMUNOCANDIDA  

Septic Shock Clinical Trial

Official title:
IMMUNOCANDIDA Candida Host Defense Response After Septic Shock in the Critically Ill

Clinical Trial Summary

Septic shock is associated with acquired immunoparalysis which is associated with a high risk of nosocomial acquired infection. Nosocomial candidiasis is associated with a 50% rate of mortality but is difficult to diagnose. The use of colonization indexes and risk factors on the other hand expose to unnecessary use of antifungals. The aim of the present study is to evaluate whether the host response to infection associated with candida biomarkers would help to anticipate the candidiasis onset.

Clinical Trial Description

Single center prospective observationnal study. Inclusion: all consecutive patients subsequently to a septic shock with no Candida infection.

Measured parameters: host response (HLADR, CD64, inflammatory cytokines consecutive to LPS exposition) and Candida biomarkers (beta D Glucan, Mannan Ag and Ig), demographics, outcome (occurence of Candida nosocomial infection, morbidity and survival) ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03136081
Study type Observational
Source University Hospital, Montpellier
Contact
Status Completed
Phase N/A
Start date June 2014
Completion date May 2015
View Details
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