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What Should be the Next Vasopressor for Severe Septic Shock? Methylene Blue or Terlipressin

Septic Shock Clinical Trial

Official title:
What Should be the Next Vasopressor for Severe Septic Shock Patients? Methylene Blue or Terlipressin

Clinical Trial Summary

The ICU mortality rate of patients with septic shock was still high upto 54.1%.In first 6 hours of resuscitation, the goals of resuscitation in sepsis shock after adequate fluid resuscitation is MAP ≥65 mmHg. In refractory septic shock patient, prolong shock correlate with poor outcome due to multiple organ failure. Alternative vasopressor in septic shock with catecholamine resistance has been studied such as terlipressin, methylene blue

- Terlipressin (TP) mediate vasoconstriction via V1 receptors coupled to phospholipase C, and increases intracellular Ca2+ concentration

- Methylene blue (MB) directly inhibits nitric oxide synthase (NOS) by inhibit the enzyme guanylate cyclase (GC)

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03038503
Study type Interventional
Source Ramathibodi Hospital
Contact munthana sundusadee, MD
Phone 66639010178
Email opal_janeway@hotmail.com
Status Recruiting
Phase Phase 3
Start date December 2016
Completion date December 2018
View Details
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