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Propafenone Versus Amiodarone in Septic Shock — PRASE  

Septic Shock Clinical Trial

Official title:
Prospective Randomized Study of Efficacy and Safety of 1c Class Antiarrhythmic Agent (Propafenone) in Septic Shock

Clinical Trial Summary

Arrhythmias accompany septic shock in increased rates than in other ICU cohorts and their presence and management are related to patient´s prognosis. 1c class antiarrhythmics are seldom administered in intensive care due to a dose dependent toxicity published in case reports and unfavourable outcome reported in a few prospective trials done on cardiology patients. The papers on 1c class antiarrhythmics do not take into consideration a complex haemodynamic assessment using echocardiography. The authors have recently presented a retrospective study on SV arrhythmias in septic shock patients demonstrating favourable effect and safety of propafenone which showed higher antiarrhythmic efficacy than amiodarone.

Clinical Trial Description

Primary aim is to verify the conclusions of the retrospective study, i.e. efficacy and safety of propafenone, in a prospective blinded randomized trial performed in two large intensive care units. Secondary aims are to monitor the electromechanics of left atrium in patients with SV arrhythmias in septic shock. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03029169
Study type Interventional
Source Charles University, Czech Republic
Contact
Status Completed
Phase Phase 4
Start date October 23, 2017
Completion date August 1, 2022
View Details
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