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Pharmacokinetic Study on Echinocandins for Patients With Septic Shock Following Secondary Peritonitis

Septic Shock Clinical Trial

Official title:
Pharmacokinetic Study on Echinocandins for Patients With Septic Shock Following Secondary Peritonitis

Clinical Trial Summary

The main objective of this study is to describe the pharmacokinetics of the prescribed echinocandins for septic shock with secondary peritonitis for which intra-abdominal fungal infection is suspected or proven.

Clinical Trial Description

The secondary objectives of this study are:

- Determine whether the current recommended doses of caspofungin achieve the Pharmacokinetic/Pharmacodynamic (PK/PD) target for this molecule.

- Determine whether the current recommended doses of micafungin achieve the PK / PD target for this molecule

- Describe the peritoneal concentrations of echinocandins in secondary peritonitis complicated with septic shock

- Identify via modeling PK / PD parameters and based on monte Carlo simulations the optimal dosing regimen for caspofungin and micafungin in this population ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02805049
Study type Interventional
Source Centre Hospitalier Universitaire de Nimes
Contact
Status Completed
Phase Phase 4
Start date January 28, 2017
Completion date June 23, 2018
View Details
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