Septic Shock Clinical Trial
Official title:
Clock Genes in Patients With Refractory Septic Shock (SeptiClock) - Pilot Study
Despite large efforts trying to improve diagnostic and therapy of sepsis have been made over
the last decade (e.g. initiation of the Surviving Sepsis Campaign, defining evidence based
sepsis therapy bundles) the mortality of septic shock remains high and causes high
socioeconomical burden of disease.
The purpose of this pilot study is to evaluate the design and conduct of a projected full
scale clinical trial.
A functional clock is required for induction of several proinflammatory genes, not shown in
septic patient settings, yet.
Clock genes are involved in modulating the activity of several transcription factors that are
important regulators of immune functions (e.g. HIF1-α, STAT1, STAT3, and NF-κB) (Bellet MM et
al., 2013).
Furthermore, polymorphisms such as rs7221412, a common polymorphism near period homolog 1
(PER1), was associated with the timing of activity rhythms and also showed a suggestive
time-dependent relationship with both cerebral cortex and monocytes PER1 expression and an
association with time of death (Lim ASP et al., 2012).
This explorative project is a pilot study. First data are generated for the assessment of the
circadian system in patients with septic shock.
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