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Upregulation of Alpha-1 Receptors Upon Septic Shock? — CATACHOC  

Septic Shock Clinical Trial

Official title:
Up Regulation of Alpha-1 Receptors Upon Septic Shock ?

Clinical Trial Summary

The hallmarks of septic shock are hypovolemia and reduced pressor response to endogenous noradrenaline. The working hypothesis is that the higher the plasma concentration of endogenous noradrenaline will be, the lower the pressor response to exogenous noradrenaline will be. This will be tested in patients presenting with septic shock, following state of the art management (including repeated assessment of vena cava diameter and compliance, and response to dynamic indices of loading) following placebo vs clonidine administration (1 mcg.kg-1.h-1 over 24 h without bolus) and administration of increasing doses of noradrenaline (1 mcg, 2 mcg, etc. up to a delta systolic blood pressure circa 25-30 mm Hg).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01856517
Study type Interventional
Source Direction Centrale du Service de Santé des Armées
Contact
Status Terminated
Phase Phase 2/Phase 3
Start date August 2013
Completion date September 2014
View Details
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