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Assessment of Fluid Responsiveness by Elevation of PEEP in Patients With Septic Shock

Septic Shock Clinical Trial

Official title:
Assessment of Fluid Responsiveness by Elevation of PEEP in Patients With Septic Shock

Clinical Trial Summary

The aim of the study is to evaluate whether fluid responsiveness of the critically ill patient can be assessed by analysing the PEEP-induced hemodynamic effects to systolic blood pressure, pulse pressure, aortic blood flow, aortic time-velocity integral and left ventricular end diastolic area measured with transesophageal echocardiography (PEEP-test). The chances are compared to increase of CI after volume expansion (gold standard). In clinical practise, it would be especially relevant if PEEP-induced changes in arterial pressure variations could be used in evaluation of volume status and fluid responsiveness. However, as ECHO-derived variables are used in greater extent to guide the treatment with inappropriate evidence, the simultaneous registration of ECHO-derived hemodynamic measurements is essential in the study design.

Clinical Trial Description

n/a

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01827007
Study type Interventional
Source Helsinki University Central Hospital
Contact
Status Completed
Phase N/A
Start date January 2008
Completion date February 2013
View Details
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