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NCT01604551 Clinical Trial

Membrane Shedding During Septic Shock

Septic Shock Clinical Trial

Official title:
Membrane Shedding During Severe Sepsis and Septic Shock: Pathophysiological and Clinical Relevance

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01604551
Other study ID # 4649
Secondary ID
Status Completed
Phase N/A
First received May 21, 2012
Last updated May 31, 2012
Start date May 2003
Est. completion date December 2011

Study information
Verified date May 2012
Source University Hospital, Strasbourg, France
Contact n/a
Is FDA regulated No
Health authority France: AFFSAPS
Study type Observational

Clinical Trial Summary

Microparticles (MPs) result from plasma cell membrane remodeling and shedding after cell stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with emerging role in pathophysiology of immune and cardiovascular diseases. MPs have been characterized during septic shock and may contribute to dissemination of pro-inflammatory and procoagulant mediators. This is a prospective observational study of circulating MPs and blood coagulation in 100 septic shock patients admitted in 3 tertiary hospitals medical ICU at baseline (D1), D2, D3, D4 and D7.

Recruitment information / eligibility
Status Completed
Enrollment 100
Est. completion date December 2011
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 85 Years
Eligibility Inclusion Criteria:

- Septic shock

- Informed consent

Exclusion Criteria:

- Class IV heart failure

- Child-Plugh grade C cirrhosis

- Cancer under active treatment

- BMI>35 kg/m²

- Moribund patient

- DNR decision

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
France Service Réanimation Médicale et Médecine Hyperbare, CHU Angers
France Centre Hospitalier Mulhouse
France Service de Réanimation Médicale, Nouvel Hôpital Civil, Hôpitaux Universitaires Strasbourg

Sponsors (1)
Lead Sponsor Collaborator
University Hospital, Strasbourg, France

Country where clinical trial is conducted

France, 

See also
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