Role of MSCT Volumetry in Assessment of Brain Atrophy in Septic Patients

Sepsis-Associated Encephalopathy Clinical Trial

Official title:

Role of Semi-automatic MSCT Volumetry in Assessment of Rapidly Progressive Brain Atrophy in Septic ICU Patients.

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06112119
• Other study ID #: sepsis and brain atrophy
• Status: Not yet recruiting
• Start date: November 1, 2023
• Est. completion date: December 30, 2024

Study information

• Verified date: October 2023
• Source: Assiut University
• Contact: Nada mohamed abdelmoneim
• Phone: 01097151396
• Email: abdelmoneimnada44[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

assessment of brain atrophy associated with septic ICU patients by using MSCT Volumetry

Description:

Sepsis is the leading cause of admission to ICU , the number of patients who survive and discharge from ICU has also increased due to technological advances in ICU however quality of life of these patients after ICU discharge is lower than that of healthy people of a similar age, in particular Sepsis associated encephalopathy associated with brain dysfunction.

We hypothesized that brain damage including brain volume reduction that ocurre in acute phase of Sepsis using CT scan and there finding " relationship to risk factor and outcome".

We compared head CT finding at time of admission with those obtained during the course of the treatment

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 55
• Est. completion date: December 30, 2024
• Est. primary completion date: November 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 16 Years to 45 Years

Eligibility

Inclusion Criteria:

• patients >16years old with sepsis associated with disturbance in conscious level admitted to ICU

Exclusion Criteria:

• Age< 16y Brain death Hematological disease Malignant disease Hypoxemia Error in automatic tissue classification Motion artifac

Related Conditions & MeSH terms

• Atrophy
• Brain Diseases
• Sepsis-Associated Encephalopathy

Intervention

Device:
• MSCT
Using Semi-automatic MSCT Volumetry in assessment of brain atrophy associated with septic ICU patients

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (1)

Nakae R, Sekine T, Tagami T, Murai Y, Kodani E, Warnock G, Sato H, Morita A, Yokota H, Yokobori S. Rapidly progressive brain atrophy in septic ICU patients: a retrospective descriptive study using semiautomatic CT volumetry. Crit Care. 2021 Nov 29;25(1):411. doi: 10.1186/s13054-021-03828-7. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	- Correlation between sepsis and brain volume reduction . - Determine the role of the CT scan in assess brain volume in acute phase of sepsis and it,s influences in improvement activities of daily living.	- Determine the role of the CT scan in assess brain volume in acute phase of sepsis and it,s influences in improvement activities of daily living after discharge from ICU.	follow up through 10 days after admission in ICU

External Links

•   retrospective study using semi automatic volumetry