Sensorineural Hearing Loss Clinical Trial
Official title:
The Effect of Sound Stimulation on Hearing Ability
In the late 1990s, researchers discovered that acoustic stimuli slow progressive
sensorineural hearing loss and exposure to a moderately augmented acoustic environment can
delay the loss of auditory function. In addition, prolonged exposure to an augmented
acoustic environment could improve age-related auditory changes. These ameliorative effects
were shown in several types of mouse strains, as long as the acoustic environment was
provided prior to the occurrence of severe hearing loss.
In addition to delaying progressive hearing loss, acoustic stimuli could also protect
hearing ability against damage by traumatic noise. In particular, a method called forward
sound conditioning (i.e., prior exposure to moderate levels of sound) has been shown to
reduce noise-induced hearing impairment in a number of mammalian species, including humans.
Interestingly, recent report has suggested that low-level sound conditioning also reduces
free radical-induced damage to hair cells, increases antioxidant enzyme activity, and
reduces Cox-2 expression in cochlea, and can enhance cochlear sensitivity. Specifically,
increased cochlear sensitivity was observed when distortion product otoacoustic emissions
(DPOAEs) and compound action potentials (CAPs) were measured.
In addition to forward sound conditioning, backward sound conditioning (i.e., the use of
acoustic stimuli after exposure to a traumatic noise) has been shown to protect hearing
ability against acoustic trauma and to prevent the cortical map reorganization induced by
traumatic noise.
In this study, the investigators examine the effect of sound stimulation on hearing ability
in human subjects.
n/a
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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