Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03019224
Other study ID # 104/2015
Secondary ID
Status Completed
Phase Phase 4
First received December 19, 2016
Last updated January 11, 2017
Start date January 2016
Est. completion date August 2016

Study information

Verified date January 2016
Source University of Campinas, Brazil
Contact n/a
Is FDA regulated No
Health authority Brazil: Ethics Committee
Study type Interventional

Clinical Trial Summary

Introduction: The pain sensitivity associated with whitening is the main problem reported by patients during dental whitening, and the use of desensitizing dentifrices is an alternative for the treatment of sensitivity.

Objective: To evaluate clinically the influence of desensitizing dentifrices applied through a plastic tray, reducing the pain sensitivity and color variation caused by the technique of in-office dental whitening, through a controlled double-blind clinical study.

Methods: A longitudinal prospective study was conducted with 48 individuals, 18 years and 30 years of age, without gender distinction, who underwent in-office dental whitening using 35% hydrogen peroxide (Whiteness HP, FGM, Joinville , SC, Brazil) in three clinical sessions with a one-week interval between them. The volunteers used in the night for each bleaching session a plastic tray for 4 hours containing one of the dentifrices related to the experimental groups: Group 1 (Control) - Sucralose (S) (Biotype - Manipulation pharmacy); Group 2 (Active control) - Sodium fluoride (FS) with 1450ppm of fluorine (Close up triple, Unilever); Group 3 - Arginine, calcium carbonate (ACC) and sodium monofluorophosphate with 1450 ppm fluorine (Colgate sensitive pro-relief, Colgate-Palmolive); Group 4 - 5% potassium nitrate (NP) and sodium fluoride with 1450 ppm fluorine (Sensodyne pro-enamel, GlaxoSmithKline). The evaluation of the sensitivity associated with the times of use of the plastic tray in the first session (S1: sensitivity before the tray, S2: sensitivity after the tray), in the second session (S3: sensitivity before the tray, S4: in the third session (S5: sensitivity before the tray, S6: sensitivity after the tray) used the analog numerical scale with scores from 0 to 10 and for the color evaluation the spectrophotometer (Easyshade, Vident, Brea, CA, Obtaining the data that were used in the CIELab system. The data were submitted to the multivariate analysis of variance (MANOVA) with repeated measurements and Lambda Wilks test with a 5% probability level to differentiate the groups. In addition, the factorial variance analysis (ANOVA) in one criterion was applied. Values of p <0.05 were considered statistically significant.


Recruitment information / eligibility

Status Completed
Enrollment 4
Est. completion date August 2016
Est. primary completion date April 2016
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 30 Years
Eligibility Inclusion Criteria:

- age of 18 years or older

- good oral and general health

- hygid anterior tooth with color shade higher than A2 on the Vita Classic scale (VITA Zahnfabrink, Bad Säckingen, Germany).

Exclusion Criteria:

- smoking, pregnancy or breastfeeding

- previous dental whitening

- para-functional habits

- dentin sensitivity

- anterior tooth with restorations and carious lesions

- non-vital discoloration

- unsatisfactory restorations

Study Design

Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Double Blind (Caregiver, Investigator), Primary Purpose: Treatment


Related Conditions & MeSH terms


Intervention

Procedure:
Selection and preparation of the volunteers
Patients who sought the postgraduate dental clinic for whitening were invited to participate in the study. They were informed by the researcher (dentist) about all the aspects of the study and who might participate or discontinue the participation at any moment during the treatment. In addition, it was clarified that their participation was voluntary and refusal to participate would not result in any penalty or loss of benefits.
Evaluation of the tooth color
The evaluation of the tooth color was performed by using a spectrophotometer (Easyshade, Vident, Brea, CA, USA). The color was analysed with the tooth hydrated before of the start the first whitening session and one week after. The spectrophotometer was always used in the same position by a silicon guide, which was prepared with dental arch molds by adding high viscosity vinyl polysiloxane material (Express XT, 3M ESPE, Sumaré, SP, Brazil). After polymerization, an opening was made in the mold corresponding to the buccal surface of the upper central incisors, allowing the color of the tooth to be evaluated with the tip of the spectrophotometer at the height of the middle third.
Relative isolation
The clinical procedures were performed under relative isolation using lip retractor (Arcflex, FGM, Joinville, SC, Brazil) and dental cotton rollers to apply a gingival protection barrier (Top Dam, FGM, Joinville, SC, Brazil) extending from right first molar to left first molar in both arches.
Gingival protection barrier
The gingival protection barrier was placed over the margins and gingival papilla corresponding to the areas receiving the whitening gel with approximately 3 mm in height and photopolymerized for 20 seconds in each group of three tooth. Photo-activation was performed with high power LEDs (light intensity = 600mw / cm²) (RadiiCal, São Paulo, SP, Brazil).
Application of desensitizing gel
The desensitizing gel containing 5% potassium nitrate associated with 2% sodium fluoride (Desensibilize KF 2%, FGM, Joinville, SC, Brazil) was applied with a microbrush (Brush KG, KG Sorensen, Cotia, SP) on the buccal surface from right first molar to left first molar in both arches and remaining for 10 minutes. Then, the desensitizer was then removed with water jet and disposable plastic suction cannula.
Drug:
Hydrogen peroxide
The handling of 35% hydrogen peroxide (Whiteness HP, FGM, Joinville, SC, Brazil) followed the manufacturer's recommendations, which consisted of mixing 3 drops of 35%hydrogen peroxide for 1 drop of thickener, with this mixture being sufficient for application to at least three tooth. The gel remained in contact with the buccal surface of the tooth for 15 minutes and was removed with disposable plastic suction cannula and water wash. This procedure was performed three times per clinical session. The volunteers underwent three whitening clinical sessions with one week interval between them.
Procedure:
Used a dentifrice
Among the clinical whitening sessions, each volunteer used an unidentified dentifrice corresponding to their experimental group, which was previously defined by means of a draw made by a dentist who did not participate in the study. Thus, the researcher (dentist) who provided the dentifrice and the volunteer were not aware of which experimental group belonged (i.e. double blind).

Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
University of Campinas, Brazil

Outcome

Type Measure Description Time frame Safety issue
Primary The analysis of the reduction of sensitivity using the toothpaste during whitening. For sensitivity analysis was used the numerical analogue scale with scores ranging from 0 to 10. Through study completion up to 4 weeks placement of the tray. No
Primary The evaluation of the tooth color using the toothpaste during whitening. For evaluation of the tooth color was performed by using a spectrophotometer. (Easyshade, Vident, Brea, CA, USA). The color was determined by EasyShade device. Through study completion up to 4 weeks placement of the tray. No
See also
  Status Clinical Trial Phase
Completed NCT03283072 - Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults N/A
Completed NCT04757454 - Performance Indicators of the SARC-F Questionnaire in Acute Care
Completed NCT03792178 - Evaluation of Post-operative Sensitivity of Bulk Fill Resin Composite Versus the Nano Resin Composite. N/A
Recruiting NCT02834585 - Magnetic Resonance Imaging or Ultrasound in Soft Tissue Tumors (MUSTT) N/A
Not yet recruiting NCT06448169 - Observational Study on the Sensitivity of Neoadjuvant Immunotherapy in Early Triple-Negative Breast Cancer
Recruiting NCT02825407 - Creation and Characterization of Two Groups of Subjects to Evaluate Sensitivity N/A
Terminated NCT05429307 - Turkish Adaptation, Validity and Reliability of Exercise Sensitivity Questionnaire
Completed NCT04477408 - Effect of Plantar Sensory Exercises on Balance and Fall Risk in Nursing Home Elderly N/A
Recruiting NCT04505046 - Validation of INSPiRED Innovative Smart Diagnostic Devices for the Detection of Parasites Infections.
Not yet recruiting NCT04762940 - INTENSIVE TREATMENT WITH ROBOTIC PLUS VIBRATION IN STROKE N/A
Completed NCT05474521 - Evaluation of Illinois Agility Performance With Smartphone Applications: A Validity and Reliability Study N/A
Completed NCT03568695 - Detection of Chlamydia Trachomatis, Neisseria Gonorrhoeae and Mycoplasma Genitalium by Real-time Multiplex Polymerase Chain Reaction (PCR) After Pooling Pharyngeal, Anorectal and Urinary Samples N/A
Completed NCT03031392 - Sensitivity and Specificity of Peri-Implantitis-Related Parameters N/A
Not yet recruiting NCT04091776 - CT Scan in Per-trochanteric Fractures N/A
Not yet recruiting NCT05185544 - Combining Genomics and Imageomics to Predict the Sensitivity of Neoadjuvant Pemetrexed and Cisplatin Chemotherapy in Patients With Lung Adenocarcinoma
Recruiting NCT03358992 - Clinical Evaluation for Sarcoma Originated From Bone
Recruiting NCT05811559 - Investigation of Sensory Processing Patterns of Elderly Individuals Who Have Had Hip Fracture Surgery
Recruiting NCT04700748 - Diffusion-weighted MRI to Predict Treatment Response in Stereotactic Radiotherapy of Central Nervous System (CNS) Metastases N/A
Completed NCT05024669 - Efficacy of Desensitizers in Reducing Post-operative Sensitivity Following Composite Restorations N/A