Sensitivity Clinical Trial
Official title:
Effects of Desensitizing Dentifrices on the Reduction of Pain Sensitivity Caused by In-office Dental Whitening: Double Blind Controlled Clinical Study
Verified date | January 2016 |
Source | University of Campinas, Brazil |
Contact | n/a |
Is FDA regulated | No |
Health authority | Brazil: Ethics Committee |
Study type | Interventional |
Introduction: The pain sensitivity associated with whitening is the main problem reported by
patients during dental whitening, and the use of desensitizing dentifrices is an alternative
for the treatment of sensitivity.
Objective: To evaluate clinically the influence of desensitizing dentifrices applied through
a plastic tray, reducing the pain sensitivity and color variation caused by the technique of
in-office dental whitening, through a controlled double-blind clinical study.
Methods: A longitudinal prospective study was conducted with 48 individuals, 18 years and 30
years of age, without gender distinction, who underwent in-office dental whitening using 35%
hydrogen peroxide (Whiteness HP, FGM, Joinville , SC, Brazil) in three clinical sessions
with a one-week interval between them. The volunteers used in the night for each bleaching
session a plastic tray for 4 hours containing one of the dentifrices related to the
experimental groups: Group 1 (Control) - Sucralose (S) (Biotype - Manipulation pharmacy);
Group 2 (Active control) - Sodium fluoride (FS) with 1450ppm of fluorine (Close up triple,
Unilever); Group 3 - Arginine, calcium carbonate (ACC) and sodium monofluorophosphate with
1450 ppm fluorine (Colgate sensitive pro-relief, Colgate-Palmolive); Group 4 - 5% potassium
nitrate (NP) and sodium fluoride with 1450 ppm fluorine (Sensodyne pro-enamel,
GlaxoSmithKline). The evaluation of the sensitivity associated with the times of use of the
plastic tray in the first session (S1: sensitivity before the tray, S2: sensitivity after
the tray), in the second session (S3: sensitivity before the tray, S4: in the third session
(S5: sensitivity before the tray, S6: sensitivity after the tray) used the analog numerical
scale with scores from 0 to 10 and for the color evaluation the spectrophotometer
(Easyshade, Vident, Brea, CA, Obtaining the data that were used in the CIELab system. The
data were submitted to the multivariate analysis of variance (MANOVA) with repeated
measurements and Lambda Wilks test with a 5% probability level to differentiate the groups.
In addition, the factorial variance analysis (ANOVA) in one criterion was applied. Values of
p <0.05 were considered statistically significant.
Status | Completed |
Enrollment | 4 |
Est. completion date | August 2016 |
Est. primary completion date | April 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 30 Years |
Eligibility |
Inclusion Criteria: - age of 18 years or older - good oral and general health - hygid anterior tooth with color shade higher than A2 on the Vita Classic scale (VITA Zahnfabrink, Bad Säckingen, Germany). Exclusion Criteria: - smoking, pregnancy or breastfeeding - previous dental whitening - para-functional habits - dentin sensitivity - anterior tooth with restorations and carious lesions - non-vital discoloration - unsatisfactory restorations |
Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Double Blind (Caregiver, Investigator), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
University of Campinas, Brazil |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The analysis of the reduction of sensitivity using the toothpaste during whitening. | For sensitivity analysis was used the numerical analogue scale with scores ranging from 0 to 10. | Through study completion up to 4 weeks placement of the tray. | No |
Primary | The evaluation of the tooth color using the toothpaste during whitening. | For evaluation of the tooth color was performed by using a spectrophotometer. (Easyshade, Vident, Brea, CA, USA). The color was determined by EasyShade device. | Through study completion up to 4 weeks placement of the tray. | No |
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