Effects of Desensitizing Dentifrices on the Reduction of Pain Sensitivity

Status Completed

Clinical Trial Summary

Introduction: The pain sensitivity associated with whitening is the main problem reported by patients during dental whitening, and the use of desensitizing dentifrices is an alternative for the treatment of sensitivity.

Objective: To evaluate clinically the influence of desensitizing dentifrices applied through a plastic tray, reducing the pain sensitivity and color variation caused by the technique of in-office dental whitening, through a controlled double-blind clinical study.

Methods: A longitudinal prospective study was conducted with 48 individuals, 18 years and 30 years of age, without gender distinction, who underwent in-office dental whitening using 35% hydrogen peroxide (Whiteness HP, FGM, Joinville , SC, Brazil) in three clinical sessions with a one-week interval between them. The volunteers used in the night for each bleaching session a plastic tray for 4 hours containing one of the dentifrices related to the experimental groups: Group 1 (Control) - Sucralose (S) (Biotype - Manipulation pharmacy); Group 2 (Active control) - Sodium fluoride (FS) with 1450ppm of fluorine (Close up triple, Unilever); Group 3 - Arginine, calcium carbonate (ACC) and sodium monofluorophosphate with 1450 ppm fluorine (Colgate sensitive pro-relief, Colgate-Palmolive); Group 4 - 5% potassium nitrate (NP) and sodium fluoride with 1450 ppm fluorine (Sensodyne pro-enamel, GlaxoSmithKline). The evaluation of the sensitivity associated with the times of use of the plastic tray in the first session (S1: sensitivity before the tray, S2: sensitivity after the tray), in the second session (S3: sensitivity before the tray, S4: in the third session (S5: sensitivity before the tray, S6: sensitivity after the tray) used the analog numerical scale with scores from 0 to 10 and for the color evaluation the spectrophotometer (Easyshade, Vident, Brea, CA, Obtaining the data that were used in the CIELab system. The data were submitted to the multivariate analysis of variance (MANOVA) with repeated measurements and Lambda Wilks test with a 5% probability level to differentiate the groups. In addition, the factorial variance analysis (ANOVA) in one criterion was applied. Values of p <0.05 were considered statistically significant.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Double Blind (Caregiver, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03019224
Study type	Interventional
Source	University of Campinas, Brazil
Contact
Status	Completed
Phase	Phase 4
Start date	January 2016
Completion date	August 2016

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03283072` - Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults	N/A
Completed	`NCT04757454` - Performance Indicators of the SARC-F Questionnaire in Acute Care
Completed	`NCT03792178` - Evaluation of Post-operative Sensitivity of Bulk Fill Resin Composite Versus the Nano Resin Composite.	N/A
Recruiting	`NCT02834585` - Magnetic Resonance Imaging or Ultrasound in Soft Tissue Tumors (MUSTT)	N/A
Recruiting	`NCT02825407` - Creation and Characterization of Two Groups of Subjects to Evaluate Sensitivity	N/A
Terminated	`NCT05429307` - Turkish Adaptation, Validity and Reliability of Exercise Sensitivity Questionnaire
Completed	`NCT04477408` - Effect of Plantar Sensory Exercises on Balance and Fall Risk in Nursing Home Elderly	N/A
Recruiting	`NCT04505046` - Validation of INSPiRED Innovative Smart Diagnostic Devices for the Detection of Parasites Infections.
Not yet recruiting	`NCT04762940` - INTENSIVE TREATMENT WITH ROBOTIC PLUS VIBRATION IN STROKE	N/A
Completed	`NCT05474521` - Evaluation of Illinois Agility Performance With Smartphone Applications: A Validity and Reliability Study	N/A
Completed	`NCT03568695` - Detection of Chlamydia Trachomatis, Neisseria Gonorrhoeae and Mycoplasma Genitalium by Real-time Multiplex Polymerase Chain Reaction (PCR) After Pooling Pharyngeal, Anorectal and Urinary Samples	N/A
Completed	`NCT03031392` - Sensitivity and Specificity of Peri-Implantitis-Related Parameters	N/A
Not yet recruiting	`NCT04091776` - CT Scan in Per-trochanteric Fractures	N/A
Not yet recruiting	`NCT05185544` - Combining Genomics and Imageomics to Predict the Sensitivity of Neoadjuvant Pemetrexed and Cisplatin Chemotherapy in Patients With Lung Adenocarcinoma
Recruiting	`NCT03358992` - Clinical Evaluation for Sarcoma Originated From Bone
Recruiting	`NCT05811559` - Investigation of Sensory Processing Patterns of Elderly Individuals Who Have Had Hip Fracture Surgery
Recruiting	`NCT04700748` - Diffusion-weighted MRI to Predict Treatment Response in Stereotactic Radiotherapy of Central Nervous System (CNS) Metastases	N/A
Completed	`NCT05024669` - Efficacy of Desensitizers in Reducing Post-operative Sensitivity Following Composite Restorations	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Effects of Desensitizing Dentifrices on the Reduction of Pain Sensitivity Caused by In-office Dental Whitening

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms