Hypersensitivity Pneumonitis of Domestic Origin

Status Not yet recruiting

Clinical Trial Summary

Exposure to molds in dwellings is a public health problem. Diagnosis of hypersensitivity pneumonitis due to mold exposure at home (domestic HP) are increasing. To perform the serodiagnosis of domestic HP a cohort constitued of proven cases and exposed healthy controls are needed. The HOME HP study aimed at obtaining a cohort of proven cases and exposed controls in order to be able to improve the serodiagnosis of domestic HP.

Clinical Trial Description

Hypersensitivy pneumonitis (HP) are chronic respiratory diseases due to frequent exposure to high quantities of allergens (molds, bacteria, mycobacteria, avian proteins). In case of domestic HP, patients are exposed at home to molds due to flooding or poor ventilation. The diagnosis of domestic HP includes detection of IgG towards molds. A prior study in 2005 allowed the determination of frequent allergenic molds isolated in homes in Bourgogne Franche Comte (study on 110 dwellings). However, no real cohort of proven cases versus controls is available. So, we are lacking validated thresholds. The HOME HP study is a prospective study that will include several centers of pneumology on France territory. The fungal contamination of dwellings occupied by patients suffering of interstitial disease (DIP), including suspicion of domestic HP, will be analyzed. The most frequently isolated molds will be then produced as antigens and will be tested in order to assess the sensitization of the included patients. The data of imagery, BALF cytology will allow to determine if patients are diagnosed with domestic HP or not. We will then obtain 2 groups of patients 1-proven domestic HP and 2-non domestic HP . Comparing the number of immunization arcs between the 2 groups will then be possible to validate appropriate thresholds for the serodiagnosis of domestic HP. Domestic HP are rare diseases, so a high number of inclusions will be needed to obatin in 2 years about 25-30 proven cases. The HOME HP study is important to improve the serodiagnosis of domestic HP. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05704218
Study type	Interventional
Source	Centre Hospitalier Universitaire de Besancon
Contact	Anne-Pauline BELLANGER
Phone	0370632351
Email	apbellanger@chu-besancon.fr
Status	Not yet recruiting
Phase	N/A
Start date	February 2023
Completion date	March 2026

View Details

See also
Status	Clinical Trial	Phase
Withdrawn	`NCT03376204` - Pain Mechanisms in Patients With Bronchiectasis
Not yet recruiting	`NCT05902702` - Isotonic Saline for Children With Bronchiolitis	N/A
Recruiting	`NCT05246098` - REVIVe: Frailty, Rehabilitation, and Outcomes in Critically Ill Adult and Pediatric Survivors of COVID-19 or ARI
Completed	`NCT04467190` - Investigation of Inflammacheck to Measure Exhaled Breath Condensate Hydrogen Peroxide in Respiratory Conditions
Not yet recruiting	`NCT05374148` - Respiratory Health Problems Among Workers in Ferrosilicon Alloys Industry in Aswan-Eygpt.
Recruiting	`NCT04502368` - Fiberoptic Bronchoscopy and Bronchoalveolar Lavage in Critically Ill Ventilated Patients
Recruiting	`NCT05775952` - Airway Remodeling and Rhinovirus in Asthmatics
Active, not recruiting	`NCT02681848` - What Are the Effects of Varenicline Compared With Nicotine Replacement Therapy on Long Term Smoking Cessation and Clinically Important Outcomes?
Recruiting	`NCT06002685` - Partners in Children's Health (CSN): A Randomized Trial of an Attachment Based Intervention	N/A
Enrolling by invitation	`NCT03319446` - Collection of Anonymized Samples	N/A
Recruiting	`NCT04287959` - SWISH Trial (Strategies for Weaning Infants on Supportive High Flow)	N/A
Completed	`NCT05017727` - Closed-loop Oxygen Control in Ventilated Infants Born at or Near Term
Completed	`NCT04607330` - Protein Top-up Acceptability Study for Patients With Increased Protein Needs	N/A
Completed	`NCT03334916` - A Clinical Trial to Evaluate the Efficacy and Safety of YMC026 in Respiratory Disease Patients	Phase 4
Completed	`NCT04649736` - Home-based Respiratory Physiotherapy and Telephone-Based Psychological Support in Severe COVID-19 Patients	N/A
Completed	`NCT03661801` - Novel Pleural Fluid, Biopsy and Serum Biomarkers for the Investigation of Pleural Effusions
Enrolling by invitation	`NCT03322254` - How Respiratory Pathogens Panel Results Affect Patients' Plan of Care
Recruiting	`NCT03937583` - Screening for Cancer in Patients With Unprovoked VTE	Phase 4
Not yet recruiting	`NCT06026163` - Caffeine as an Adjuvant Therapy for Late Preterm Infants With Respiratory Distress	Phase 2/Phase 3
Completed	`NCT04581096` - Mapping COVID-19 Spread in a Tertiary Hospital

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Hypersensitivity Pneumonitis of Domestic Origin — HOME-HP

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms