Selenium Status Clinical Trial
Official title:
Investigating Flavour-nutrient Learning in Humans Using Selenium-enriched Parsnips
Study aims to investigate 2 topics:
1. Flavour-Nutrient Learning (FNL) FNL proposes that personal food preferences may be
influenced by unconscious mechanisms which operate to ensure the safeguarding of
individual nutrient levels. The theory postulates that food preferences may change over
time to address changing nutritional status (Yeomans, 2012).
This study aims to explore FNL in humans by investigating the preferences of
participants with low and high blood-selenium levels in relation to selenium-enriched
parsnips. Participants will be investigated in a two-week trial in which they will
undertake two food sensory tests: one before, and one after, the two-week period where
they will incorporate provided parsnips into their diet.
Some provided parsnips will contain higher levels of selenium than others, neither the
participants nor the lead researcher will know which type of parsnip each participant
receives.
It is hypothesised that the second food sensory test, performed after the intervention
period, will show that participants of lower initial blood-selenium levels will
demonstrate an increased liking for the selenium-enriched parsnips. This may demonstrate
possible FNL in humans.
2. Relationship between selenium intake & plasma selenium-status. This study will also
examine the relationship (if any) between the selenium intake of all participants via
the different types of parsnips, and their individual blood-selenium levels.
This will be assessed via blood tests before, during and after the trial in order to observe
the blood-selenium levels of each participant.
It is hypothesised that the blood-selenium levels of participants of lower initial selenium
readings will be the most improved upon consumption of selenium-enriched parsnips.
1. FNL Despite a wealth of animal studies (Amanoel et al, 2016; Bach et al, 2012), human
FNL research is in relative infancy.
This study intends to investigate FNL in humans by exploring preferences of participants
of different selenium-status regarding selenium-enriched parsnips, with non-enriched
parsnips and other root vegetables to be used as comparators.
Participants will be assessed by means of food sensory tests and blood analysis before,
during and after the trial period.
The trial aims to recruit 26 lower selenium-status participants of initial
selenium-status approx. 70μg/L, and 26 higher selenium-status participants of initial
selenium-status approx. 100μg/L (n=52). (Initial screening sample approx. n=120.) On
initial screening, potential participants recording a selenium-status of under 28μg/L or
over 400μg/L will be excluded (and their GP informed) for safety reasons.
Re parsnips:
Selenium-enriched parsnips: Se content approx. 0.30ppm. Placebo comparator:
non-selenium-enriched parsnips: Se content approx. 0.06ppm. Treatment portion: 200g
fresh weight per day for 14 days. Comparator vegetables: potato, celeriac, turnip.
2. Relationship between selenium intake & plasma selenium-status. This study will also
investigate the relationship, if any, between the selenium intake of all participants
via the different types of parsnips and their individual selenium status. This will be
assessed via blood tests before, during and after the trial in order to observe
plasma-selenium status.
This is deemed an important area for research as research suggests a trend towards selenium
deficiency in the United Kingdom population (SACN, 2013). It is hoped the current study may
inform the debate regarding the potential of improving United Kingdom's population selenium
status via selenium-fortified foods.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03770676 -
Investigating the Sensory Attributes of Selenium-fortified Biscuits and Their Effects on Selenium-status
|
N/A | |
| Completed |
NCT01224249 -
Selenium Status Measured in Blood After a Higher Intake of Fish and Shellfish - a Randomized Dietary Intervention Study
|
Phase 1 |