Seizures Clinical Trial
— ONSDOfficial title:
Does Optic Nerve Sheath Diameter and Its Ratio to Eyeball Transverse Diameter Correlate With the Duration of Seizures in Post-ictal Children?
Verified date | June 2024 |
Source | Balikesir University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
A total of 88 postictal children with generalized or focal seizures were included in the study. The ONSD and ONSD/ETD ratio was measured independently by a pediatric neurologist and pediatric emergency expert, three times in both eyes using non-contrasted computed tomography taken within one hour after the seizure. The characteristics of seizures (duration, etiology, initiated treatment, and frequency) were recorded. Non-traumatic patients with normal head computed tomography findings at the hospital admission were considered as the control group (n=109).
Status | Completed |
Enrollment | 197 |
Est. completion date | December 1, 2022 |
Est. primary completion date | December 1, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 1 Year to 18 Years |
Eligibility | Inclusion Criteria: - seizures were observed by a health worker or directly with home videos. - prolonged seizures were used: those lasting more than 5 minutes for focal seizures and more than 10 minutes for generalized seizures. Exclusion Criteria: - Incomplete medical records; prior intracranial lesions, such as cysts (arachnoid, and pineal cysts), - Chiari malformations, sequelae gliotic lesions, or incidental space-occupying lesions (cavernoma, lipoma, etc.); - Chronic neuromuscular disease, metabolic or genetic disorders; - Ocular trauma, periorbital cellulitis glaucoma, refraction errors, or optic disc drusen; or a history of retinopathy of prematurity - Images with streak and movement artifacts, as well as images with pathologies that prevent measurement of the ONSD |
Country | Name | City | State |
---|---|---|---|
Turkey | Balikesir Ataturk City Hospital | Balikesir | Altieylul |
Lead Sponsor | Collaborator |
---|---|
Balikesir University |
Turkey,
Handan Gunsay R, Cikrikci Isik G, Yildirim M, Gokcek O, Korucu O, Cevik Y. Evaluation of postictal optic nerve sheath diameter at epileptic patients. Epilepsy Behav. 2023 Jul;144:109264. doi: 10.1016/j.yebeh.2023.109264. Epub 2023 May 27. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | elevated ICP in postictal cildren | The investigators aim to show that elevated ICP which caused by prolonged seizures in children might be measured by optic nerve sheath diameter (ONSD) and ONSD/eyeball transverse diameter (ETD) ratios by head CT. | 0-4 hours of emergengy department admission | |
Primary | to prove seizures cause elevated ICP by measuring optic nerve sheath diameter (ONSD) and optic nerve in sheath diameter to eyeball transverse diameter (ETD) ratio and comparing these results with healthy controls | The investigators aim to prove that pediatric seizures cause elevated ICP. This could be predicted by measuring optic nerve sheath diameter (ONSD) and optic nerve sheath diameter to eyeball transverse diameter (ETD) ratio. And compare these measurements with healthy controls. | 4th to 5th hour of emergengy department admission | |
Primary | to prove various seizure types cause variations in ICP and to show these can be detected by measuring optic nerve sheath diameter (ONSD) and optic nerve in sheath diameter to eyeball transverse diameter (ETD) ratio | The investigators aim to detect the difference in ICP by measuring optic nerve sheath diameter (ONSD) and optic nerve sheath diameter to eyeball transverse diameter (ETD) ratio in children with focal and generalized seizures.And compare these results. | 4th to 5th hour of emergengy department admission |
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