Boosting The Intervention Effect of Negative Memory Through tACS Stimulation

Seizures Clinical Trial

Official title:

Research on Improving the Intervention Effect of Negative Memory Through tACS Enhanced Memory Technology

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06375395
• Other study ID #: Memory Updating Tasks
• Status: Not yet recruiting
• Phase: N/A
• Start date: May 15, 2024
• Est. completion date: December 31, 2024

Study information

• Verified date: November 2023
• Source: Xuanwu Hospital, Beijing
• Contact: Hongxing Wang, MD & PhD
• Phone: 01083198513
• Email: hxwang8888[@]126.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The objectives of this study include: 1) investigating the impact of negative memory substitution on an individual's other intellectual memories (i.e., neutral memories) and the underlying neurocognitive mechanisms; 2) investigating the memory enhancement effect resulting from retrieval practice associated with memory substitution intervention along with an examination of the neurocognitive mechanisms responsible for this enhancement.

Description:

This study will adopt two memory updating strategies: retrieval practice and reactivation.

A 5-day memory updating experimental paradigm is used.

1. On the first day, the old memory A-B linkage is learned, where A represents a neutral word and B is either neutral or negative pictures (half of each, randomly scrambled).

2. On the second day, the old memory A-B association is consolidated again, and after a 15-minute break, the new memory A-C association is learned, where A is still the word A used in the old memory A-B association on the first day, and C is the new neutral and negative pictures (half of each, randomly scrambled, and with inconsistent categories of C and B in each pair of AC and AB). Immediately following this, the new memories of the A-C conjunctions are updated using both Retrieval practice and Restudy (control condition) memory strategies.

3. A-C is extracted/learned using both Retrieval practice and Restudy memory strategies on both day 3 and day 4.

4. On the fifth day, memory tests for associative memory strength, gist and detail memory, as well as emotional valence and strength are performed.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 60
• Est. completion date: December 31, 2024
• Est. primary completion date: December 15, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 14 Years to 60 Years

Eligibility

Eligibility

Inclusion Criteria:

1. 14-60 years old, male or female, Han Chinese;

2. Drug-resistant epilepsy;

3. Required surgical implantation of SEEG electrodes.

Exclusion Criteria:

1. Progressive encephalopathy or progressive structural damage in the central nervous system;

2. Significant heart, liver, renal insufficiency, and other medical diseases;

3. Severe side effects from taking antiepileptic drugs at the time of enrollment and not inappropriate for SEEG;

4. Significant intellectual disability;

5. A history of alcohol and drug abuse;

6. Any contraindication to MRI.

Related Conditions & MeSH terms

• Seizures

Intervention

Device:
• Active tACS Device
Transcranial Alternating Current Stimulation
• Sham tACS Device
Placebo Device that simulates active tACS treatment

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Xuanwu Hospital, Beijing	Beijing Normal University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Negative memory retention	The intervention could disrupt retention of associative negative memory and degree of detail of the negative memories in last A-C paired associate memory test.	Day 5
Secondary	The negative emotional intensity of negative memory	The negative memories emotional relief as assesses by the Self-Assessment Manikin (SAM) Measure Scales in last A-C paired associate memory test.; This measure is constant retrieval practice of neutral memories (A-Cneu) will result in negative memories emotional relief (A-Bneg) compared to the restudy condition.	Day 5
Secondary	The retention of associated neutral memories as assesses by the proportions of responses of correctly choosing picture category of B picture (A-Bneu) in last A-B paired associate memory test	This measure is continuous rumination of negative memories (A-Cneg) will increase the strength of associated memories (A-Bneu).	Day 5
Secondary	The negative emotional intensity of neutral memory	The emotion-diffusing effects of negative memory rumination as assesses by negative emotional intensity of neutral memories (A-Bneu),which is meature by the Self-Assessment Manikin (SAM) Measure Scales. The negative emotional intensity of neutral memories are more negative with constant retrieval practice of negative memories (A-Cneg) that is the emotion-diffusing effects of negative memory rumination.	Day 5