Febrile Illness in Children Clinical Trial
Official title:
Investigation of the Respiratory Physiology of Children With and Without Febrile Seizures During Febrile Illness.
Febrile seizures occur in 2-5% of the population and are typically limited to children
between 3 months and 5 years-of-age. The pathophysiological link between increased body
temperature and increased seizure susceptibility is unsolved in humans. In a mouse model it
has been shown that young animals had a tendency to hyperventilate thereby causing
intra-cerebral hypocapnia / alkalosis and a decrease of their seizure threshold. This effect
was not observed in older animals. Redressing the pCO2 (carbon dioxide partial pressure) by
breathing carbon dioxide enriched air instantly stopped the seizures.
In this study the investigators want to investigate the respiratory physiology in children
with febrile seizures and compare it to children who have fever but did not have febrile
seizures.
The investigators hypothesize that in children with febrile seizures the rising body
temperature triggers a larger increase of respiratory rate (hyperventilation) and subsequent
drop in pCO2 levels.
This study could provide the basic physiological data for an interventional trial to test
the efficacy of carbon dioxide inhalation to interrupt febrile seizures.
The aim of the study is the continuous non-invasive monitoring of
- body temperature
- respiratory rate
- transcutaneous pCO2
- heart rate
- pulsoxymetric SaO2 (arterial oxygen saturation) during a febrile illness
- in children without febrile seizures and
- in children who had suffered a febrile seizure during the actual febrile illness.
Children will be recruited from the emergency units of the Charité University Hospital and a
large Community Hospital, matched according to age, gender and the cause of their febrile
illness and their data will enter final analysis if their body temperature rose at least
once to or above 38.0 degree C and changed more than 1.0 degree C during the observational
period.
;
Observational Model: Case Control, Time Perspective: Prospective