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Clinical Trial Summary

The purpose of this study is to determine if antiepileptic drugs (AEDs) differ in their neurodevelopmental effects. Specifically, do the children of the women with epilepsy differ in their behavioral and cognitive development depending on which AED their mother takes during pregnancy?


Clinical Trial Description

This is a prospective investigation enrolling 285 to 380 women with epilepsy during the first two trimesters of their pregnancies. There are 25 clinical centers as well as the database center. The women will be taking one of the following AEDs: carbamazepine, phenytoin, valproate, or lamotrigine. Cognitive and behavioral testing of the child will be done up to the age of 6 years. The study does not change the woman's doctor and does not interfere with the care of the treating physician. ;


Study Design

Observational Model: Family-Based, Time Perspective: Prospective


Related Conditions & MeSH terms


NCT number NCT00021866
Study type Observational
Source Emory University
Contact
Status Completed
Phase N/A
Start date September 2000
Completion date August 2012

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