Pathophysiology Based Therapy of Early Onset Epileptic Encephalopathies

Seizure, Epileptic Clinical Trial

— EE  

Official title:

Pathophysiologie Basierte Therapie Von früh Beginnenden Epileptischen Enzephalopathien

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT02968966
• Other study ID #: AKF 357-0-0
• Status: Withdrawn
• Phase: Phase 2
• Start date: December 1, 2018
• Est. completion date: August 2020

Study information

• Verified date: February 2020
• Source: University Hospital Tuebingen
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Genetic epileptic encephalopathies (EEs) are a group of very rare and severe, pharmaco-resistant epilepsy forms characterized by an early onset, e.g. first years of life, and an often severe developmental delay. Genetic defects were found in different ion channels such as potassium or sodium channels explaining well the pathological neuronal hyperexcitability leading to seizures. Further mutations were also found in proteins relevant for cell structure, DNA/RNA processing or the synaptic vesicular metabolism. Specific and individualized therapies have not been established neither in the clinical routine nor in controlled studies. The goal of this monocentric non-blinded non-placebo controlled phase IIb study is the evaluation of the effectivity of anticonvulsive drugs specifically working on the ion channels defective in some subtypes of EEs in order to establish a standard and individualized therapy for these rare diseases based on the specific genetic defect.

Description:

During the study, the sodium channel blockers phenytoin and lacosamide and the potassium channel blocker kinidinsulfate will be given under standardized conditions to patients with an early onset and pharmaco-resistant genetic epilepsy with and without mutations in the potassium channels KCNT1 and KCNQ2 and the sodium channel gene SCN2A. The primary endpoint will be a significant seizure reduction under trial medication compared to baseline. Secondary endpoints will be the improvement of electroencephalographic characteristics of the respective EEs.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: August 2020
• Est. primary completion date: May 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A to 12 Months

Eligibility

Inclusion Criteria:

• highly active epilepsy (= 1 seizure per day)

• epilepsy with onset 0-3 months of age

• pharmaco-resistant epilepsy (2 or more standard anticonvulsive medications tried before)

• recently max. two stable anticonvulsive drugs for minimum 4 days before study start

• patients under continuous monitoring control

• patients younger than 1 year of age

Exclusion Criteria:

• high grade cardial rhythm disorders

• severe liver, renal and electrolyte blood parameter changes

• metabolic or lesional origin of epilepsy (metabolic screening results and cranial MRI available)

• parallel participation in other studies (must be finished two month before study start)

• missing informed consent

Related Conditions & MeSH terms

• Epilepsy
• Seizure, Epileptic
• Seizures

Intervention

Other:
• Therapy regime
Patient will receive Phenytoin, if no success is obtained, Vimpat is given. In case of success after one of the treatments, the endpoint is reached. Success is defined as reduction of seizures to 50% compared to baseline.

Locations

Country	Name	City	State
Germany	Universtiy Hospital	Tübingen

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital Tuebingen

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Reduction of seizures	Reduction of epileptic seizures within one treatment phase to 50% compared to baseline	one week
Secondary	Reduction of seizures stratified for genetic background	Reduction of epileptic seizures within one treatment phase to 50% compared to baseline stratified for three gene mutations	one week
Secondary	Reduction of epileptic activities or suppression phases	Reduction of epileptic activities or suppression phases in EEG	one week